Lange, Naomi F; Graf, Vanessa; Caussy, Cyrielle; Dufour, Jean-François (2022). PPAR-Targeted Therapies in the Treatment of Non-Alcoholic Fatty Liver Disease in Diabetic Patients. International journal of molecular sciences, 23(8) MDPI 10.3390/ijms23084305
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Peroxisome proliferator-activated receptors (PPAR), ligand-activated transcription factors of the nuclear hormone receptor superfamily, have been identified as key metabolic regulators in the liver, skeletal muscle, and adipose tissue, among others. As a leading cause of liver disease worldwide, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) cause a significant burden worldwide and therapeutic strategies are needed. This review provides an overview of the evidence on PPAR-targeted treatment of NAFLD and NASH in individuals with type 2 diabetes mellitus. We considered current evidence from clinical trials and observational studies as well as the impact of treatment on comorbid metabolic conditions such as obesity, dyslipidemia, and cardiovascular disease. Future areas of research, such as possible sexually dimorphic effects of PPAR-targeted therapies, are briefly reviewed.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Lange, Naomi Franziska, Graf, Vanessa |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1422-0067 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
26 Apr 2022 12:29 |
Last Modified: |
02 Mar 2023 23:36 |
Publisher DOI: |
10.3390/ijms23084305 |
PubMed ID: |
35457120 |
Uncontrolled Keywords: |
non-alcoholic fatty liver disease (NAFLD) non-alcoholic steatohepatitis (NASH) peroxisome proliferator-activated receptors (PPAR) type 2 diabetes mellitus |
BORIS DOI: |
10.48350/169486 |
URI: |
https://boris.unibe.ch/id/eprint/169486 |
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