Lever, Mael; Chen, Ying; Glaser, Moritz; Unterlauft, Jan Darius; Lommatzsch, Claudia; Bechrakis, Nikolaos E; Böhm, Michael R R (2022). Microvascular and Morphologic Changes of the Macula over Lifetime. Life, 12(4) MDPI 10.3390/life12040568
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In ocular, neurologic, and cardiovascular diseases, macular segmentation data from spectral-domain optical coherence tomography (SD-OCT) provide morphologic, and OCT-angiography (OCTA) results give microvascular information about the macula. Age was shown to influence both methods' measurements. To further characterize this association, macular SD-OCT and OCTA changes were investigated in a population of juvenile, adult, and older individuals. Macular segment thickness and superficial (SCP) and deep plexus (DCP) vascular density (VD) of 157 healthy individuals aged 10-79 years were analyzed retrospectively. One-way analysis of variance (ANOVA) was used to compare age groups. The association between macular segmentation and OCTA parameters and between these and age was evaluated using linear regression. ANOVA and linear regression analysis showed a thickness decrease in the whole macular and in the ganglion cell and inner plexiform layers with age. While the foveal avascular zone area remained constant between age groups, VD of the SCP and DCP also decreased with age. In multiple linear regression, SCP and DCP VD were associated with inner macular segment thickness in an age-independent way. To conclude, the age-related microvascular and morphological changes in the macula described in this study can contribute to improving the understanding of macular aging processes and better interpreting OCT(A) results in healthy individuals and patients suffering from various retinal diseases.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Unterlauft, Jan Darius |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2075-1729 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
26 Apr 2022 14:23 |
Last Modified: |
05 Dec 2022 16:19 |
Publisher DOI: |
10.3390/life12040568 |
PubMed ID: |
35455059 |
Uncontrolled Keywords: |
aging blood flow capillary density macula macular segmentation optical coherence tomography-angiography vascular disease |
BORIS DOI: |
10.48350/169491 |
URI: |
https://boris.unibe.ch/id/eprint/169491 |
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