Eppenberger, Daria; Nilius, Henning; Anagnostelis, Betsy; Huber, Carola A; Nagler, Michael (2022). Current Knowledge on Factor V Leiden Mutation as a Risk Factor for Recurrent Venous Thromboembolism: A Systematic Review and Meta-Analysis. Frontiers in cardiovascular medicine, 9, p. 883986. Frontiers 10.3389/fcvm.2022.883986
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Background
Thrombophilia screening is widely done in clinical practice, and it is claimed that the extent of venous thromboembolism (VTE) recurrence risk in patients with common defects is still not fully understood.
Aim
We aimed to summarize data of all observational studies prospectively assessing the association of heterozygous factor V Leiden (FVL) mutation and recurrent VTE in patients with VTE, and to calculate pooled relative risks (RR), overall and in various subgroups.
Methods
We searched MEDLINE and EMBASE databases for cohort studies prospectively assessing VTE recurrence in patients with and without FVL mutation (PROSPERO: CRD42021182800). Data were extracted on cohort and study-level. The methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). RR were calculated overall and in subgroups using a random-effects model.
Results
From 31 cohorts, 24 studies were finally included summarizing 13,571 patients. Heterozygous FVL mutation was identified in 2,840 individuals (21%). The methodological quality was estimated to be high in 20 studies (83%). The overall RR was 1.46 (95% CI: 1.31, 1.64), consistent across subgroups.
Conclusions
Pooling all high-quality epidemiological data, the risk of recurrent VTE was increased by 46% in patients with heterozygous FVL mutation. Against the background of established risk factors, the FVL mutation plays only a marginal role in the risk assessment for recurrent VTE.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry 13 Central Units > Administrative Director's Office > University Library of Bern |
UniBE Contributor: |
Nilius, Henning Jürgen Jean, Anagnostelis, Betsy, Nagler, Michael |
Subjects: |
600 Technology > 610 Medicine & health 000 Computer science, knowledge & systems > 020 Library & information sciences |
ISSN: |
2297-055X |
Publisher: |
Frontiers |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
26 Apr 2022 12:08 |
Last Modified: |
05 Dec 2022 16:19 |
Publisher DOI: |
10.3389/fcvm.2022.883986 |
PubMed ID: |
35463779 |
Uncontrolled Keywords: |
heterozygous factor V Leiden mutation prospective cohort studies recurrent venous thromboembolism risk factors systematic review |
BORIS DOI: |
10.48350/169519 |
URI: |
https://boris.unibe.ch/id/eprint/169519 |
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