Impairment of sleep homeostasis in cervical dystonia patients.

Caverzasio, Serena; Amato, Ninfa; Chiaro, Giacomo; Staedler, Claudio; Kaelin-Lang, Alain; Galati, Salvatore (2022). Impairment of sleep homeostasis in cervical dystonia patients. Scientific Reports, 12(1), p. 6866. Nature Publishing Group 10.1038/s41598-022-10802-y

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Alterations in brain plasticity seem to play a role in the pathophysiology of cervical dystonia (CD). Since evidences indicate that sleep regulates brain plasticity, we hypothesized that an alteration in sleep homeostatic mechanisms may be involved in the pathogenesis of CD. We explored sleep in control subjects (CTL) and CD patients before (Tpre-BoNT) and after (Tpost-BoNT) botulinum toxin (BoNT) treatment. A physiological slow wave activity (SWA) power decrease throughout the night was observed in CTL but not in CD at Tpre-BoNT. BoNT restored the physiological SWA decrease in CD at Tpost-BoNT. Furthermore, in the first part of the night, CD at Tpost-BNT showed a frontal increase and parietal decrease in SWA power compared to CD at Tpre-BoNT, with a SWA distribution comparable to that observed in CTL. Our data highlighted a pathophysiological relationship between SWA during sleep and CD and provided novel insight into the transient central plastic effect of BoNT.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Kaelin, Alain

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2045-2322

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Pubmed Import

Date Deposited:

29 Apr 2022 11:39

Last Modified:

01 May 2022 06:26

Publisher DOI:

10.1038/s41598-022-10802-y

PubMed ID:

35477733

BORIS DOI:

10.48350/169627

URI:

https://boris.unibe.ch/id/eprint/169627

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