Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: an observational study.

Casaulta, Carmen; Messerli, Florence; Rodriguez, Romy; Klein, Andrea; Riedel, Thomas (2022). Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: an observational study. Scientific reports, 12(1), p. 7009. Springer Nature 10.1038/s41598-022-11190-z

[img]
Preview
Text
s41598-022-11190-z.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

Patients with neuromuscular disease often suffer from weak and ineffective cough resulting in mucus retention and increased risk for chest infections. Different airway clearance techniques have been proposed, one of them being the insufflator/exsufflator technique. So far, the immediate physiological effects of the insufflator/exsufflator technique on ventilation distribution and lung volumes are not known. We aimed to describe the immediate effects of the insufflator/exsufflator technique on different lung volumes, forced flows and ventilation distribution. Eight subjects (age 5.8-15.2 years) performed lung function tests including spirometry, multiple breath washout and electrical impedance tomography before and after a regular a chest physiotherapy session with an insufflator/exsufflator device. Forced lung volumes and flows as well as parameters of ventilation distribution derived from multiple breath washout and electrical impedance tomography were compared to assess the short-term effect of the therapy. In this small group of stable paediatric subjects with neuromuscular disease we could not demonstrate any short-term effects of insufflation/exsufflation manoeuvres on lung volumes, expiratory flows and ventilation distribution. With the currently used protocol of the insufflation/exsufflation manoeuvre, we cannot demonstrate any immediate changes in lung function.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Intensive Care
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

UniBE Contributor:

Casaulta, Carmen; Messerli, Florence; Rodriguez Del Rio, Romy Melanie; Klein, Andrea Katharina and Riedel, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2045-2322

Publisher:

Springer Nature

Language:

English

Submitter:

Pubmed Import

Date Deposited:

02 May 2022 07:52

Last Modified:

08 May 2022 02:04

Publisher DOI:

10.1038/s41598-022-11190-z

PubMed ID:

35488044

BORIS DOI:

10.48350/169652

URI:

https://boris.unibe.ch/id/eprint/169652

Actions (login required)

Edit item Edit item
Provide Feedback