Marine biome-derived secondary metabolites, a class of promising antineoplastic agents: A systematic review on their classification, mechanism of action and future perspectives.

Sugumaran, Abimanyu; Pandiyan, Rajesh; Kandasamy, Palanivel; Antoniraj, Mariya Gover; Navabshan, Irfan; Sakthivel, Balasubramanian; Dharmaraj, Selvakumar; Chinnaiyan, Santhosh Kumar; Ashokkumar, Veeramuthu; Ngamcharussrivichai, Chawalit (2022). Marine biome-derived secondary metabolites, a class of promising antineoplastic agents: A systematic review on their classification, mechanism of action and future perspectives. The Science of the total environment, 836, p. 155445. Elsevier 10.1016/j.scitotenv.2022.155445

[img]
Preview
Text
1-s2.0-S0048969722025396-main.pdf - Accepted Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (1MB) | Preview

Cancer is one of the most deadly diseases on the planet. Over the past decades, numerous antineoplastic compounds have been discovered from natural resources such as medicinal plants and marine species as part of multiple drug discovery initiatives. Notably, several marine flora (e.g. Ascophyllum nodosum, Sargassum thunbergii) have been identified as a rich source for novel cytotoxic compounds of different chemical forms. Despite the availability of enormous chemically enhanced new resources, the anticancer potential of marine flora and fauna has received little attention. Interestingly, numerous marine-derived secondary metabolites (e.g., Cytarabine, Trabectedin) have exhibited anticancer effects in preclinical cancer models. Most of the anticancer drugs obtained from marine sources stimulated apoptotic signal transduction pathways in cancer cells, such as the intrinsic and extrinsic pathways. This review highlights the sources of different cytotoxic secondary metabolites obtained from marine bacteria, algae, fungi, invertebrates, and vertebrates. Furthermore, this review provides a comprehensive overview of the utilisation of numerous marine-derived cytotoxic compounds as anticancer drugs, as well as their modes of action (e.g., molecular target). Finally, it also discusses the future prospects of marine-derived drug developments and their constraints.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Nephrologie / Hypertonie

UniBE Contributor:

Kandasamy, Palanivel

ISSN:

1879-1026

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

03 May 2022 10:44

Last Modified:

02 May 2023 00:25

Publisher DOI:

10.1016/j.scitotenv.2022.155445

PubMed ID:

35490806

Uncontrolled Keywords:

Anticancer agents Apoptosis Drug discovery Marine microorganisms Marine-derived products Secondary metabolites

BORIS DOI:

10.48350/169702

URI:

https://boris.unibe.ch/id/eprint/169702

Actions (login required)

Edit item Edit item
Provide Feedback