Sex and gender differences in anticancer treatment toxicity - a call for revisiting drug dosing in oncology.

Özdemir, Berna C; Gerard, Camille L; Espinosa da Silva, Cristina (2022). Sex and gender differences in anticancer treatment toxicity - a call for revisiting drug dosing in oncology. Endocrinology, 163(6) Endocrine Society 10.1210/endocr/bqac058

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The practice of oncology has dramatically changed in the last decade with the introduction of molecular tumor profiling into routine tumor diagnostics and the extraordinary progress in immunotherapies. However, there remains an unmet need to explore personalized dosing strategies that take into account the patient's sex to optimize the balance between efficacy and toxicity for each individual patient. In this mini-review, we summarize the evidence on sex differences in toxicity of anticancer therapies and present data on dose reduction and dose discontinuation rates for selected chemotherapies and targeted therapies. Finally, we propose the investigation of body composition (specifically fat free muscle mass) as a viable approach for personalized treatment dosage.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Özdemir, Berna

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0013-7227

Publisher:

Endocrine Society

Language:

English

Submitter:

Pubmed Import

Date Deposited:

06 May 2022 10:51

Last Modified:

01 Apr 2023 00:11

Publisher DOI:

10.1210/endocr/bqac058

PubMed ID:

35511041

Uncontrolled Keywords:

body composition fat free muscle mass gender differences sex differences targeted therapies

BORIS DOI:

10.48350/169769

URI:

https://boris.unibe.ch/id/eprint/169769

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