Sparasci, Davide; Gobbi, Claudio; Castelnovo, Anna; Riccitelli, Gianna Carla; Disanto, Giulio; Zecca, Chiara; Manconi, Mauro (2022). Fatigue, sleepiness and depression in multiple sclerosis: defining the overlaps for a better phenotyping. Journal of neurology, 269(9), pp. 4961-4971. Springer 10.1007/s00415-022-11143-6
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Sparasci2022_Article_FatigueSleepinessAndDepression.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
BACKGROUND AND OBJECTIVES
To define the boundaries and the overlaps between fatigue, sleepiness and depression in patients with multiple sclerosis (MS) by using different tools for each dimension, including instrumental sleep analysis.
METHODS
In this cross-sectional, observational study, 71 MS patients (males/females: 20/51; mean age: 48.9 ± 10.5 years) filled in clinical questionnaires and performed polysomnography followed by maintenance of wakefulness test (MWT). Frequency and reciprocal overlap of sleepiness, fatigue and depression in MS were expressed by Eulero-Venn diagrams; standard multiple regression was used to assess the ability of symptoms to predict each other.
RESULTS
There was a high percentage of fatigued (70%), somnolent (45%) and depressed (27%) patients. Fatigue had the strongest overlap and correlated with both depression (beta: 0.52, p < 0.001) and sleepiness (beta: 0.74, p < 0.001). Somnolence and depression were nearly always accompanied by fatigue and were well differentiated from each other by MWT. Four MS subgroups were identified that had: (1) fatigue only; (2) fatigue and sleepiness (3) fatigue and depression; (4) fatigue, sleepiness and depression.
DISCUSSION
The subjective and objective tools are not able to clearly distinguish fatigue from sleepiness and depression, while only a test of vigilance can be helpful in separating somnolence and depression from each other.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy |
UniBE Contributor: |
Castelnovo, Anna |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1432-1459 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
06 May 2022 14:46 |
Last Modified: |
24 May 2023 11:54 |
Publisher DOI: |
10.1007/s00415-022-11143-6 |
PubMed ID: |
35507053 |
Uncontrolled Keywords: |
Depression Fatigue Maintenance of wakefulness test Multiple sclerosis Sleep |
BORIS DOI: |
10.48350/169787 |
URI: |
https://boris.unibe.ch/id/eprint/169787 |
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