Automated, 3-D and Sub-Micron Accurate Ablation-Volume Determination by Inverse Molding and X-Ray Computed Tomography.

Monserrat Lopez, Diego; Grimaudo, Valentine; Prone, Giulia; Flisch, Alexander; Riedo, Andreas; Zboray, Robert; Lüthi, Thomas; Mayor, Marcel; Fussenegger, Martin; Broekmann, Peter; Wurz, Peter; Lörtscher, Emanuel (2022). Automated, 3-D and Sub-Micron Accurate Ablation-Volume Determination by Inverse Molding and X-Ray Computed Tomography. Advanced science, 9(20), e2200136. Wiley 10.1002/advs.202200136

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Ablation of materials in combination with element-specific analysis of the matter released is a widely used method to accurately determine a material's chemical composition. Among other methods, repetitive ablation using femto-second pulsed laser systems provides excellent spatial resolution through its incremental removal of nanometer thick layers. The method can be combined with high-resolution mass spectrometry, for example, laser ablation ionization mass spectrometry, to simultaneously analyze chemically the material released. With increasing depth of the volume ablated, however, secondary effects start to play an important role and the ablation geometry deviates substantially from the desired cylindrical shape. Consequently, primarily conical but sometimes even more complex, rather than cylindrical, craters are created. Their dimensions need to be analyzed to enable a direct correlation with the element-specific analytical signals. Here, a post-ablation analysis method is presented that combines generic polydimethylsiloxane-based molding of craters with the volumetric reconstruction of the crater's inverse using X-ray computed tomography. Automated analysis yields the full, sub-micron accurate anatomy of the craters, thereby a scalable and generic method to better understand the fundamentals underlying ablation processes applicable to a wide range of materials. Furthermore, it may serve toward a more accurate determination of heterogeneous material's composition for a variety of applications without requiring time- and labor-intensive analyses of individual craters.

Item Type:

Journal Article (Original Article)


08 Faculty of Science > Physics Institute > Space Research and Planetary Sciences
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Riedo, Andreas, Broekmann, Peter, Wurz, Peter


500 Science > 520 Astronomy
600 Technology > 620 Engineering
500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry








Pubmed Import

Date Deposited:

09 May 2022 08:55

Last Modified:

05 Dec 2022 16:19

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

X-ray computed tomography femto-second laser pulses laser ablation mass spectrometry molding polydimethylsiloxane




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