Meira, Bruna; Lhommée, Eugénie; Schmitt, Emmanuelle; Klinger, Hélène; Bichon, Amélie; Pélissier, Pierre; Anheim, Mathieu; Tranchant, Christine; Fraix, Valérie; Meoni, Sara; Durif, Franck; Houeto, Jean-Luc; Azulay, Jean Philippe; Moro, Elena; Thobois, Stéphane; Krack, Paul; Castrioto, Anna (2022). Early Parkinson's Disease Phenotypes Tailored by Personality, Behavior, and Motor Symptoms. Journal of Parkinson's disease, 12(5), pp. 1665-1676. IOS Press 10.3233/JPD-213070
Full text not available from this repository. (Request a copy)BACKGROUND
Previous studies described a parkinsonian personality characterized as rigid, introverted, and cautious; however, little is known about personality traits in de novo Parkinson's disease (PD) patients and their relationships with motor and neuropsychiatric symptoms.
OBJECTIVE
To investigate personality in de novo PD and explore its relationship with PD symptoms.
METHODS
Using Cloninger's biosocial model, we assessed personality in 193 de novo PD patients. Motor and non-motor symptoms were measured using several validated scales. Cluster analysis was conducted to investigate the interrelationship of personality traits, motor, and non-motor symptoms.
RESULTS
PD patients showed low novelty seeking, high harm avoidance, and normal reward dependence and persistence scores. Harm avoidance was positively correlated with the severity of depression, anxiety, and apathy (rs = [0.435, 0.676], p < 0.001) and negatively correlated with quality of life (rs = -0.492, p < 0.001). Novelty seeking, reward dependence, and persistence were negatively correlated with apathy (rs = [-0.274, -0.375], p < 0.001). Classification of patients according to personality and PD symptoms revealed 3 distinct clusters: i) neuropsychiatric phenotype (with high harm avoidance and low novelty seeking, hypodopaminergic neuropsychiatric symptoms and higher impulsivity), ii) motor phenotype (with low novelty seeking and higher motor severity), iii) benign phenotype (with low harm avoidance and high novelty seeking, reward dependence, and persistence traits clustered with lower symptoms severity and low impulsivity).
CONCLUSION
Personality in early PD patients allows us to recognize 3 patients' phenotypes. Identification of such subgroups may help to better understand their natural history. Their longitudinal follow-up will allow confirming whether some personality features might influence disease evolution and treatment.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Krack, Paul |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1877-718X |
Publisher: |
IOS Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
10 May 2022 09:39 |
Last Modified: |
05 Dec 2022 16:19 |
Publisher DOI: |
10.3233/JPD-213070 |
PubMed ID: |
35527563 |
Uncontrolled Keywords: |
Neuropsychiatric symptoms Parkinson’s disease non-motor symptoms personality |
URI: |
https://boris.unibe.ch/id/eprint/169877 |
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