Gastens, Viktoria; Kiszio, Blanche; Del Giovane, Cinzia; Tsuyuki, Ross; Paradis, Gilles; Chiolero, Arnaud; Santschi, Valérie (2022). Pharmacist interventions to improve hypertension management: protocol for a systematic review of randomised controlled trials. BMJ open, 12(5), e059399. BMJ Publishing Group 10.1136/bmjopen-2021-059399
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INTRODUCTION
Hypertension management remains a major public health challenge in primary care. Innovative interventions to improve blood pressure (BP) control are needed. One approach is through community-based models of care with the involvement of pharmacists and other non-physician healthcare professionals. Our objective is to systematically review the evidence of the impact of pharmacist care alone or in collaboration with other healthcare professionals on BP among hypertensive outpatients compared with usual care. Because these interventions can be complex, with various components, the effect size may differ between the type of interventions. One major focus of our study will be to assess carefully the heterogeneity in the effects of these interventions to identify which ones work best in a given healthcare setting.
METHODS AND ANALYSIS
Systematic searches of the Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica (Embase) and Central Register of Controlled Trials (CENTRAL) databases will be conducted. Randomised controlled trials assessing the effect of pharmacist interventions on BP among outpatients will be included. Examples for pharmacist interventions are patient education, feedback to physician and medication management. The outcome will be the change in BP or BP at follow-up or BP control. Results will be synthesised descriptively and, if appropriate, will be pooled across studies to perform meta-analyses. If feasible, we will also perform a network meta-analysis to compare interventions that have not been compared directly head-to-head by using indirect evidence. Heterogeneity in the effect will be evaluated through prespecified subgroup and stratified analyses, accounting notably for the type and intensity of interventions, patients' characteristics and healthcare setting.
ETHICS AND DISSEMINATION
Ethical approval is not required as the results will be drawn from currently available published literature. Outcomes of the review will be shared through peer-reviewed journal and used for implementation policy.
PROSPERO REGISTRATION NUMBER
CRD42021279751.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM) |
UniBE Contributor: |
Gastens, Viktoria Marianne, Del Giovane, Cinzia |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
2044-6055 |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 May 2022 10:57 |
Last Modified: |
02 Mar 2023 23:36 |
Publisher DOI: |
10.1136/bmjopen-2021-059399 |
PubMed ID: |
35537793 |
Uncontrolled Keywords: |
CLINICAL PHARMACOLOGY EPIDEMIOLOGY HEALTH SERVICES ADMINISTRATION & MANAGEMENT Hypertension PREVENTIVE MEDICINE PUBLIC HEALTH |
BORIS DOI: |
10.48350/169904 |
URI: |
https://boris.unibe.ch/id/eprint/169904 |
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