Braccini, S; Carzaniga, T S; Dellepiane, G; Grundler, P V; Scampoli, P; van der Meulen, N P; Wüthrich, Diana (2022). Optimization of 68Ga production at an 18 MeV medical cyclotron with solid targets by means of cross-section measurement of 66Ga, 67Ga and 68Ga. Applied radiation and isotopes, 186(110252), p. 110252. Elsevier 10.1016/j.apradiso.2022.110252
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The future development of personalized nuclear medicine relies on the availability of novel medical radionuclides. In particular, radiometals are attracting considerable interest since they can be used to label both proteins and peptides. Among them, the β+-emitter 68Ga is widely used in nuclear medicine for positron emission tomography (PET). It is used in theranostics as the diagnostic partner of the therapeutic β--emitters 177Lu and 90Y for the treatment of a wide range of diseases, including prostate cancer. Currently, 68Ga is usually obtained via 68Ge/68Ga generators. However, their availability, high price and limited produced radioactivity per elution are a major barrier for a wider use of the 68Ga-based diagnostic radiotracers. A promising solution is the production of 68Ga by means of proton irradiation of enriched 68Zn liquid or solid targets. Along this line, a research program is ongoing at the Bern medical cyclotron, equipped with a solid target station. In this paper, we report on the measurements of 68Ga, 67Ga and 66Ga production cross-sections using natural Zn and enriched 68Zn material, which served as the basis to perform optimized 68Ga production tests with enriched 68Zn solid targets.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
10 Strategic Research Centers > Albert Einstein Center for Fundamental Physics (AEC) 08 Faculty of Science > Physics Institute > Laboratory for High Energy Physics (LHEP) 08 Faculty of Science > Physics Institute |
UniBE Contributor: |
Braccini, Saverio, Carzaniga, Tommaso Stefano, Dellepiane, Gaia, Wüthrich, Diana |
Subjects: |
500 Science > 530 Physics |
ISSN: |
0969-8043 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 May 2022 12:15 |
Last Modified: |
05 Dec 2022 16:19 |
Publisher DOI: |
10.1016/j.apradiso.2022.110252 |
PubMed ID: |
35537298 |
Uncontrolled Keywords: |
Cross-section Ga-68 Medical cyclotrons PET Solid target Theranostics |
BORIS DOI: |
10.48350/169907 |
URI: |
https://boris.unibe.ch/id/eprint/169907 |
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