Depression and Psychosis Risk Shared Vulnerability for Motor Signs Across Development, Symptom Dimensions, and Familial Risk.

Damme, Katherine S F; Park, Jadyn S; Walther, Sebastian; Vargas, Teresa; Shankman, Stewart A; Mittal, Vijay A (2022). Depression and Psychosis Risk Shared Vulnerability for Motor Signs Across Development, Symptom Dimensions, and Familial Risk. Schizophrenia bulletin, 48(4), pp. 752-762. Oxford University Press 10.1093/schbul/sbab133

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BACKGROUND

Motor abnormalities are strong transdiagnostic indicators of psychopathology risk that reflect emerging neural network abnormalities. Indeed, motor signs, such as motor slowing and agitation, are widely recognized as core features of both psychosis and depression. However, it is unclear whether these reflect shared or distinct etiology.

METHODS

A sample of 11 878 adolescents completed self-reported clinical measures of rated psychotic-like experiences (PLEs) and depression. Familial risk for psychopathology and the presence of motor signs were drawn from parental reports, including developmental motor delays (eg, sitting, walking), and adolescent motor signs (eg, dyscoordination, psychomotor retardation, and psychomotor agitation). Finally, motor network connectivity in theoretically relevant networks (cortico-striatal, cortico-thalamic, and cortico-cerebellar) were related to symptoms and familial risk for psychopathology.

RESULTS

Developmental motor delays related to increased PLEs, increased depression symptoms, and greater familial risk. Familial risk for both PLEs and depression showed higher rates of developmental motor delays than all other groups. Adolescent motor signs, however, showed unique patterns of relationships to symptoms and familial risk such that dyscoordination reflected risk for PLEs, both psychomotor agitation and retardation reflected depression risk, and psychomotor agitation reflected transdiagnostic risk. Cortico-striatal connectivity was related to depression and PLEs, but cortico-cerebellar connectivity was linked to PLEs only.

CONCLUSIONS

Motor signs may be a transdiagnostic marker of vulnerability for psychopathology. Early developmental motor delays could belie pluripotent, familial risk features. Unique items, eg, dyscoordination specifically related to PLEs, possibly reflecting processes inherent in distinct emerging forms of psychopathology.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0586-7614

Publisher:

Oxford University Press

Language:

English

Submitter:

Pubmed Import

Date Deposited:

16 May 2022 15:57

Last Modified:

05 Dec 2022 16:19

Publisher DOI:

10.1093/schbul/sbab133

PubMed ID:

35554607

Uncontrolled Keywords:

coordination depression motor development psychomotor agitation psychomotor retardation psychotic-like experience

BORIS DOI:

10.48350/170019

URI:

https://boris.unibe.ch/id/eprint/170019

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