Paradoxical somatodendritic decoupling supports cortical plasticity during REM sleep.

Aime, Mattia; Calcini, Niccolo; Borsa, Micaela; Campelo, Tiago; Rusterholz, Thomas; Sattin, Andrea; Fellin, Tommaso; Adamantidis, Antoine (2022). Paradoxical somatodendritic decoupling supports cortical plasticity during REM sleep. Science, 376(6594), pp. 724-730. American Association for the Advancement of Science 10.1126/science.abk2734

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Rapid eye movement (REM) sleep is associated with the consolidation of emotional memories. Yet, the underlying neocortical circuits and synaptic mechanisms remain unclear. We found that REM sleep is associated with a somatodendritic decoupling in pyramidal neurons of the prefrontal cortex. This decoupling reflects a shift of inhibitory balance between parvalbumin neuron-mediated somatic inhibition and vasoactive intestinal peptide-mediated dendritic disinhibition, mostly driven by neurons from the central medial thalamus. REM-specific optogenetic suppression of dendritic activity led to a loss of danger-versus-safety discrimination during associative learning and a lack of synaptic plasticity, whereas optogenetic release of somatic inhibition resulted in enhanced discrimination and synaptic potentiation. Somatodendritic decoupling during REM sleep promotes opposite synaptic plasticity mechanisms that optimize emotional responses to future behavioral stressors.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Aime, Mattia; Calcini, Niccolo; Borsa, Micaela; Sa Campelo, Tiago Miguel; Rusterholz, Thomas and Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0036-8075

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Pubmed Import

Date Deposited:

16 May 2022 09:06

Last Modified:

05 Dec 2022 16:19

Publisher DOI:

10.1126/science.abk2734

PubMed ID:

35549430

BORIS DOI:

10.48350/170030

URI:

https://boris.unibe.ch/id/eprint/170030

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