Ercan, Caner; Coto-Llerena, Mairene; Gallon, John; Fourie, Lana; Marinucci, Mattia; Hess, Gabriel F; Vosbeck, Jürg; Taha-Mehlitz, Stephanie; Boldanova, Tuyana; Meier, Marie-Anne; Tzankov, Alexandar; Matter, Matthias S; Hoffmann, Martin H K; Di Tommaso, Luca; von Flüe, Markus; Ng, Charlotte K. Y.; Heim, Markus H; Soysal, Savas D; Terracciano, Luigi M; Kollmar, Otto; ... (2022). Genomic analysis of focal nodular hyperplasia with associated hepatocellular carcinoma unveils its malignant potential: a case report. Communications medicine, 2, p. 11. Springer Nature 10.1038/s43856-022-00074-y
|
Text
s43856-022-00074-y.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (10MB) | Preview |
Background
Focal nodular hyperplasia (FNH) is typically considered a benign tumor of the liver without malignant potential. The co-occurrence of FNH and hepatocellular carcinoma (HCC) has been reported in rare cases. In this study we sought to investigate the clonal relationship between these lesions in a patient with FNH-HCC co-occurrence.
Methods
A 74-year-old female patient underwent liver tumor resection. The resected nodule was subjected to histologic analyses using hematoxylin and eosin stain and immunohistochemistry. DNA extracted from microdissected FNH and HCC regions was subjected to whole exome sequencing. Clonality analysis were performed using PyClone.
Results
Histologic analysis reveals that the nodule consists of an FNH and two adjoining HCC components with distinct histopathological features. Immunophenotypic characterization and genomic analyses suggest that the FNH is clonally related to the HCC components, and is composed of multiple clones at diagnosis, that are likely to have progressed to HCC through clonal selection and/or the acquisition of additional genetic events.
Conclusion
To the best of our knowledge, our work is the first study showing a clonal relationship between FNH and HCC. We show that FNH may possess the capability to undergo malignant transformation and to progress to HCC in very rare cases.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) |
UniBE Contributor: |
Ng, Kiu Yan Charlotte |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2730-664X |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
24 May 2022 16:22 |
Last Modified: |
05 Dec 2022 16:20 |
Publisher DOI: |
10.1038/s43856-022-00074-y |
PubMed ID: |
35603298 |
Uncontrolled Keywords: |
Cancer genomics Hepatocellular carcinoma |
BORIS DOI: |
10.48350/170205 |
URI: |
https://boris.unibe.ch/id/eprint/170205 |
Actions (login required)
 |
Edit item |