Ruffer, Nikolas; Krusche, Martin; Holl-Ulrich, Konstanze; Kötter, Ina; Lötscher, Fabian (2023). [Cocaine-induced vasculitis and mimics of vasculitis]. Zeitschrift für Rheumatologie, 82(7), pp. 606-614. Springer-Medizin-Verlag 10.1007/s00393-022-01217-1
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Ruffer2022_Article_Kokain-induzierteVaskulitidenU.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
Cocaine is a psychotropic tropane alkaloid and stimulant drug. Nasal insufflation of cocaine powder is a common route of administration. In Germany, cocaine is frequently adulterated with levamisole, an anthelminthic drug with immunomodulatory effects. Both substances are linked to various autoimmune conditions. Cocaine-induced midline destructive lesions cause a progressive destruction of osteocartilaginous structures within the upper respiratory tract and can mimic localized granulomatosis with polyangiitis. In addition, systemic vasculitis due to cocaine and levamisole has been reported. Differentiation of these conditions from primary vasculitis can be challenging because antineutrophil cytoplasmic antibodies (ANCA) are commonly detected. Early diagnosis of these conditions is crucial as clinical improvement is closely related to drug cessation.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology |
UniBE Contributor: |
Lötscher, Fabian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0340-1855 |
Publisher: |
Springer-Medizin-Verlag |
Language: |
German |
Submitter: |
Pubmed Import |
Date Deposited: |
27 May 2022 08:08 |
Last Modified: |
12 Sep 2023 00:11 |
Publisher DOI: |
10.1007/s00393-022-01217-1 |
PubMed ID: |
35612660 |
Uncontrolled Keywords: |
ANCA Cocaine-induced midline destructive lesions Granulomatosis with polyangiitis Levamisole Mimics |
BORIS DOI: |
10.48350/170273 |
URI: |
https://boris.unibe.ch/id/eprint/170273 |
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