Remission in schizophrenia: validity, frequency, predictors, and patients' perspective 5 years later

Lambert, Martin; Karow, Anne; Leucht, Stefan; Schimmelmann, Benno G; Naber, Dieter (2010). Remission in schizophrenia: validity, frequency, predictors, and patients' perspective 5 years later. Dialogues in clinical neuroscience, 12(3), pp. 393-407. Neuilly-sur-Seine: Les Laboratoires Servier

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In March 2005, the Remission in Schizophrenia Working Group (RSWG) proposed a consensus definition of symptomatic remission in schizophrenia and developed specific operational criteria for its assessment. They pointed out, however, that the validity and the relationship to other outcome dimensions required further examination. This article reviews studies on the validity, frequency, and predictors of symptomatic remission in schizophrenia and studies on patients' perspectives. These studies have demonstrated that the RSWG remission criteria appear achievable and sustainable for a significant proportion of patients, and are related to a better overall symptomatic status and functional outcome and, to a less clear extent, to a better quality of life and cognitive performance. However, achieving symptomatic remission is not automatically concurrent with an adequate status in other outcome dimensions. The results of the present review suggest that the RSWG remission criteria are valid and useful. As such, they should be consistently applied in clinical trials. However the lack of consensus definitions of functional remission and adequate quality of life hampers research on their predictive validity on these outcome dimensions. Future research should therefore search for criteria of these dimensions and test whether the RSWG remission criteria consistently predict a "good" outcome with respect to functioning and quality of life.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy

UniBE Contributor:

Schimmelmann, Benno Karl Edgar

ISSN:

1294-8322

Publisher:

Les Laboratoires Servier

Language:

English

Submitter:

Myriam Pyrlik

Date Deposited:

04 Oct 2013 14:11

Last Modified:

15 Jan 2014 12:53

PubMed ID:

20954433

URI:

https://boris.unibe.ch/id/eprint/1703 (FactScience: 203633)

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