Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine.

Delaval, Mathilde N; Jonsdottir, Hulda R; Leni, Zaira; Keller, Alejandro; Brem, Benjamin T; Siegerist, Frithjof; Schönenberger, David; Durdina, Lukas; Elser, Miriam; Salathe, Matthias; Baumlin, Nathalie; Lobo, Prem; Burtscher, Heinz; Liati, Anthi; Geiser, Marianne (2022). Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine. Environmental pollution, 307, p. 119521. Elsevier Science 10.1016/j.envpol.2022.119521

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Health effects of particulate matter (PM) from aircraft engines have not been adequately studied since controlled laboratory studies reflecting realistic conditions regarding aerosols, target tissue, particle exposure and deposited particle dose are logistically challenging. Due to the important contributions of aircraft engine emissions to air pollution, we employed a unique experimental setup to deposit exhaust particles directly from an aircraft engine onto re-differentiated human bronchial epithelia (HBE) at air-liquid interface under conditions similar to in vivo airways to mimic realistic human exposure. The toxicity of non-volatile PM (nvPM) from a CFM56-7B26 aircraft engine by sampling was evaluated under realistic engine conditions and exposing HBE derived from donors of normal and compromised health status to exhaust for one hour followed by biomarker analysis 24hours post exposure. Particle deposition varied depending on the engine thrust levels with 85% thrust producing the highest nvPM mass and number emissions with estimated surface deposition of 3.17 × 109 particles cm-2 or 337.1 ng cm-2. Transient increase in cytotoxicity was observed after exposure to nvPM in epithelia derived from a normal donor as well as a decrease in the secretion of interleukin 6 and monocyte chemotactic protein 1. Non-replicated multiple exposures of epithelia derived from a normal donor to nvPM primarily led to a pro-inflammatory response, while both cytotoxicity and oxidative stress induction remained unaffected. This raises concerns for the long-term implications of aircraft nvPM for human pulmonary health, especially in occupational settings.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Cell Biology
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Delaval, Mathilde, Jonsdottir, Hulda Run, Leni, Zaira, Geiser, Marianne

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0269-7491

Publisher:

Elsevier Science

Language:

English

Submitter:

Pubmed Import

Date Deposited:

30 May 2022 12:52

Last Modified:

26 May 2023 00:25

Publisher DOI:

10.1016/j.envpol.2022.119521

PubMed ID:

35623573

Uncontrolled Keywords:

Aerosol Aircraft engine exhaust Bronchial epithelial cell culture Cellular response Non-volatile particulate matter

BORIS DOI:

10.48350/170302

URI:

https://boris.unibe.ch/id/eprint/170302

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