Bako, Jozsef; Toth, Ferenc; Gall, Jozsef; Kovacs, Renato; Csík, Attila; Varga, Istvan; Sculean, Anton; Zelko, Romana; Hegedus, Csaba (2022). Combined Release of Antiseptic and Antibiotic Drugs from Visible Light Polymerized Biodegradable Nanocomposite Hydrogels for Periodontitis Treatment. Pharmaceutics, 14(5) MDPI 10.3390/pharmaceutics14050957
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The in situ application of the combination of different types of drugs revolutionized the area of periodontal therapy. The purpose of this study was to develop nanocomposite hydrogel (NCHG) as a pH-sensitive drug delivery system. To achieve local applicability of the NCHG in dental practice, routinely used blue-light photopolymerization was chosen for preparation. The setting time was 60 s, which resulted in stable hydrogel structures. Universal Britton-Robinson buffer solutions were used to investigate the effect of pH in the range 4-12 on the release of drugs that can be used in the periodontal pocket. Metronidazole was released from the NCHGs within 12 h, but chlorhexidine showed a much longer elution time with strong pH dependence, which lasted more than 7 days as it was corroborated by the bactericidal effect. The biocompatibility of the NCHGs was proven by Alamar-blue test and the effectiveness of drug release in the acidic medium was also demonstrated. This fast photo-polymerizable NCHG can help to establish a locally applicable combined drug delivery system which can be loaded with the required amount of medicines and can reduce the side effects of the systemic use of drugs that have to be used in high doses to reach an ideal concentration locally.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Sculean, Anton |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1999-4923 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
30 May 2022 09:39 |
Last Modified: |
05 Dec 2022 16:20 |
Publisher DOI: |
10.3390/pharmaceutics14050957 |
PubMed ID: |
35631542 |
Uncontrolled Keywords: |
chlorhexidine combined drug delivery hydrogel metronidazole nanocomposite photopolymerization |
BORIS DOI: |
10.48350/170318 |
URI: |
https://boris.unibe.ch/id/eprint/170318 |
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