Simultaneous gut colonization by Klebsiella grimontii and Escherichia coli co-possessing the blaKPC-3-carrying pQil plasmid.

Campos-Madueno, Edgar I.; Mauri, Carola; Meroni, Elisa; Porragas Paseiro, Pablo; Consonni, Alessandra; Luzzaro, Francesco; Endimiani, Andrea (2022). Simultaneous gut colonization by Klebsiella grimontii and Escherichia coli co-possessing the blaKPC-3-carrying pQil plasmid. European journal of clinical microbiology & infectious diseases, 41(7), pp. 1087-1091. Springer 10.1007/s10096-022-04462-z

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Only two plasmid-mediated carbapenemases (KPC-2 and VIM-1) are reported in Klebsiella grimontii. Here, we report two blaKPC-3-positive isolates that were identified as K. oxytoca and E. coli by MALDI-TOF MS in the same rectal swab. Whole-genome sequencing indicated that K. oxytoca was actually K. grimontii of ST391, whereas E. coli was of ST10. In both, blaKPC-3 was carried by a pQil conjugative plasmid. The core-genome analysis identified additional blaKPC-positive K. grimontii strains from public databases, most of which were misidentified as K. oxytoca. Since K. grimontii represents an emerging reservoir of resistance traits, routine tools should improve their ability to detect this species.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Campos-Madueno, Edgar Igor, Porragas Paseiro, Pablo, Endimiani, Andrea

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0934-9723

Publisher:

Springer

Language:

English

Submitter:

Pubmed Import

Date Deposited:

02 Jun 2022 14:36

Last Modified:

04 Aug 2023 10:51

Publisher DOI:

10.1007/s10096-022-04462-z

PubMed ID:

35643963

Uncontrolled Keywords:

Carbapenemase Conjugation K. grimontii K. oxytoca KPC Plasmid pQil

BORIS DOI:

10.48350/170409

URI:

https://boris.unibe.ch/id/eprint/170409

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