Impact of chronic coronary syndromes on cardiovascular hospitalization and mortality: The ESC-EORP CICD-LT registry.

Kerneis, Mathieu; Cosentino, Francesco; Ferrari, Roberto; Georges, Jean-Louis; Kosmachova, Elena; Laroche, Cécile; Maggioni, Aldo P; Rittger, Harald; Steg, Philippe Gabriel; Maczynska, Justyna; Tavazzi, Luigi; Valgimigli, Marco; Gale, Chris P; Komajda, Michel (2022). Impact of chronic coronary syndromes on cardiovascular hospitalization and mortality: The ESC-EORP CICD-LT registry. European journal of preventive cardiology, 29(15), pp. 1945-1954. Oxford University Press 10.1093/eurjpc/zwac089

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BACKGROUND

In Europe, global data on guideline adherence, geographic variations and determinants of clinical events in Chronic coronary syndrome (CCS) patients remain suboptimal.

DESIGN

The European Society of Cardiology (ESC) EORP CICD-LT registry is a prospective European registry, was designed to describe the profile, management and outcomes of patients with CCS across the ESC countries.

METHODS

We aimed to investigate clinical events at one-year follow-up from the ESC EORP CICD-LT Registry.

RESULTS

One-year outcomes of 6655 patients from the 9174 recruited in this European registry were analyzed. Overall, 168 patients (2.5%) died, mostly from CV causes (n= 97, 1.5%). Northern Europe had the lowest CV mortality rate, while southern Europe had the highest (0.5% vs 2.0%, p= 0.04). Women had a higher rate of CV mortality compared with men (2.0% vs 1.3%, p = 0.02). During follow-up, 1606 patients (27.1%) were hospitalized at least once, predominantly for CV indications (n = 1220, 20.6%). Among the population with measured LDL-cholesterol level at one-year, 1434 patients (66.5%) were above the recommended target. Age, history of atrial fibrillation, previous stroke, liver disease, chronic obstructive pulmonary disease or asthma, increased serum creatinine and impaired left ventricular function were associated with an increased risk of CV death or hospitalization.

CONCLUSION

In the CICD registry, the majority of patients with CCS have uncontrolled CV risk factors. The one year mortality rate is low, but these patients are frequently hospitalized for CV causes. Early identification of comorbidities may represent an opportunity for enhanced care and better outcomes.

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