Elective percutaneous liver biopsy and use of aspirin.

Reynard, Maxence Emmanuel; Dufour, Jean-François (2022). Elective percutaneous liver biopsy and use of aspirin. United European gastroenterology journal, 10(6), pp. 538-543. Wiley 10.1002/ueg2.12254

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OBJECTIVES

Percutaneous liver biopsy is an essential diagnostic investigation in hepatology. Among complications, which are rare, bleeding is the most feared. Many patients scheduled for a liver biopsy are taking aspirin. Surprisingly no information is available in the literature on this frequent clinical situation. The American Association for the Study of Liver Diseases (AASLD) position paper on percutaneous liver biopsy does not specifically recommend stopping low dose aspirin prior to an elective percutaneous liver biopsy. The European Association for the Study of the Liver also remains unspecific without giving clear recommendation on stopping or not low dose aspirin before the procedure. The aim of this study is to document current practice concerning the management of patients scheduled for an elective percutaneous biopsy and taking low dose aspirin.

DESIGN

An online questionnaire was designed to gather data on current practice on the perioperative management of percutaneous liver biopsy and use of aspirin.

SETTINGS

The questionnaire was emailed to AASLD members in September 2018.

PARTICIPANTS

Four hundred sixty six responses were collected.

RESULTS

Seventy eight percent postpone elective percutaneous liver biopsy if International Normalised Ratio is ≥1.5 or Quick ≤50%. Ninety five percent postpone biopsy if platelet count is ≤50,000 × 106 /L. Seventy five percent stop low dose aspirin, on average, 6 days prior to the percutaneous liver biopsy. This choice of management does not seem to be related to previous complications since 86% report not having experienced any bleeding in patients taking low dose aspirin. Nevertheless, this practice has logistic consequences since 61% of the respondents postponed a liver biopsy due to intake of low dose aspirin.

CONCLUSIONS

Despite the lack of clear statement in guidelines and evidence supporting this practice, three quarters of physicians practicing in hepatology stop low dose aspirin before elective percutaneous liver biopsy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

UniBE Contributor:

Dufour, Jean-François

ISSN:

2050-6414

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

03 Jun 2022 09:45

Last Modified:

05 Dec 2022 16:20

Publisher DOI:

10.1002/ueg2.12254

PubMed ID:

35652196

Uncontrolled Keywords:

aspirin bleeding liver biopsy liver disease

BORIS DOI:

10.48350/170430

URI:

https://boris.unibe.ch/id/eprint/170430

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