Kahn, Martin; Krone, Lukas B; Blanco-Duque, Cristina; Guillaumin, Mathilde C C; Mann, Edward O; Vyazovskiy, Vladyslav V (2022). Neuronal-spiking-based closed-loop stimulation during cortical ON- and OFF-states in freely moving mice. Journal of sleep research, 31(6), e13603. Wiley 10.1111/jsr.13603
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Journal_of_Sleep_Research_-_2022_-_Kahn_-_Neuronal_spiking_based_closed_loop_stimulation_during_cortical_ON__and_OFF_states.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (2MB) | Preview |
The slow oscillation is a central neuronal dynamic during sleep, and is generated by alternating periods of high and low neuronal activity (ON- and OFF-states). Mounting evidence causally links the slow oscillation to sleep's functions, and it has recently become possible to manipulate the slow oscillation non-invasively and phase-specifically. These developments represent promising clinical avenues, but they also highlight the importance of improving our understanding of how ON/OFF-states affect incoming stimuli and what role they play in neuronal plasticity. Most studies using closed-loop stimulation rely on the electroencephalogram and local field potential signals, which reflect neuronal ON- and OFF-states only indirectly. Here we develop an online detection algorithm based on spiking activity recorded from laminar arrays in mouse motor cortex. We find that online detection of ON- and OFF-states reflects specific phases of spontaneous local field potential slow oscillation. Our neuronal-spiking-based closed-loop procedure offers a novel opportunity for testing the functional role of slow oscillation in sleep-related restorative processes and neural plasticity.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy |
UniBE Contributor: |
Krone, Lukas |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1365-2869 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
08 Jun 2022 12:01 |
Last Modified: |
05 Dec 2022 16:20 |
Publisher DOI: |
10.1111/jsr.13603 |
PubMed ID: |
35665551 |
Uncontrolled Keywords: |
closed-loop stimulation cortical layers mice neocortex sleep sleep homeostasis slow wave detection |
BORIS DOI: |
10.48350/170459 |
URI: |
https://boris.unibe.ch/id/eprint/170459 |
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