An Evaluation of Periodontal Status and Cytokine Levels in Saliva and Gingival Crevicular Fluid of Patients with Inflammatory Bowel Diseases.

Enver, Ayaz; Ozmeric, Nurdan; Isler, Sila Cagri; Toruner, Murat; Fidan, Cigdem; Demirci, Gulsah; Elgun, Serenay; DA Silva, Andre Paes B (2022). An Evaluation of Periodontal Status and Cytokine Levels in Saliva and Gingival Crevicular Fluid of Patients with Inflammatory Bowel Diseases. Journal of periodontology, 93(11), pp. 1649-1660. Wiley 10.1002/JPER.22-0065

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AIMS

Periodontal diseases and inflammatory bowel diseases (IBD, ulcerative colitis [UC] and Crohn's disease [CD]) have been reported to present with increased salivary and gingival crevicular fluid (GCF) concentrations of cytokines. The aim of this study was to evaluate the salivary and GCF levels of TNF-α, IL-1β, IL-10, and IL-17A and their associations with the periodontal statuses of UC, CD and non-IBD patients, and to analyze the interrelationships among these cytokines, IBD conditions, and periodontal diseases.

MATERIALS AND METHODS

This cross-sectional study was performed with a total of 131 patients (62 women and 69 men, mean age 42.96±13.02 years). Patients were divided into three groups: UC, CD, and non-IBD. Periodontal status was defined according to the 2017 World Workshop Disease Classification. Salivary and GCF cytokine levels were analyzed using ELISA.

RESULTS

UC and CD patients diagnosed as having periodontitis and gingivitis presented with significantly higher levels of TNF-α and lower levels of IL-10 as compared with non-IBD patients (p<0.05). UC patients diagnosed with periodontitis exhibited significantly higher scores of bleeding on probing (p = 0.011) and increased salivary and GCF IL-1β levels as compared with CD patients (p = 0.005, and 0.012 respectively). Considering the active and remission status of IBD, salivary IL-1β was found to be correlated with the parameters representing the severity of periodontal diseases in active UC and CD patients.

CONCLUSION(S)

In the presence of periodontal diseases, UC and CD patients showed different expression levels of TNF-α, IL-1β, and IL-10 in oral secretions as compared with non-IBD patients. This article is protected by copyright. All rights reserved.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > School of Dental Medicine

UniBE Contributor:

Isler, Sila Cagri

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1943-3670

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

08 Jun 2022 08:45

Last Modified:

05 Dec 2022 16:20

Publisher DOI:

10.1002/JPER.22-0065

PubMed ID:

35665507

Uncontrolled Keywords:

cytokines gingival crevicular fluid periodontal diseases saliva, Crohn's disease, Ulcerative colitis

BORIS DOI:

10.48350/170460

URI:

https://boris.unibe.ch/id/eprint/170460

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