Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities.

Liu, Cong; Cai, Jing; Chen, Renjie; Sera, Francesco; Guo, Yuming; Tong, Shilu; Li, Shanshan; Lavigne, Eric; Correa, Patricia Matus; Ortega, Nicolas Valdes; Orru, Hans; Maasikmets, Marek; Jaakkola, Jouni J K; Ryti, Niilo; Breitner, Susanne; Schneider, Alexandra; Katsouyanni, Klea; Samoli, Evangelina; Hashizume, Masahiro; Honda, Yasushi; ... (2022). Coarse Particulate Air Pollution and Daily Mortality: A Global Study in 205 Cities. American journal of respiratory and critical care medicine, 206(8), pp. 999-1007. American Thoracic Society 10.1164/rccm.202111-2657OC

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RATIONALE

The associations between ambient coarse particulate matter (PM2.5-10) and daily mortality is not fully understood at a global scale.

OBJECTIVES

To evaluate the short-term associations between PM2.5-10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide.

METHODS

We collected daily mortality (total, cardiovascular, respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5-10 were computed as the difference between inhalable and fine particulate matter. A two-stage time-series analytic approach was applied, with over-dispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5-10 from co-pollutants (fine particulate matter, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure-response relationship curves were pooled and regional analyses were conducted.

MEASUREMENTS AND MAIN RESULTS

A 10 μg/m3 increase in PM2.5-10 concentration on lag 0-1 day was associated with increments of 0.51% (95% confidence interval [CI]: 0.18%, 0.84%), 0.43% (95%CI: 0.15%, 0.71%) and 0.41% (95%CI: 0.06%, 0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all co-pollutants in two-pollutant models, especially for PM2.5. The exposure-response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds.

CONCLUSIONS

This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5-10 and total, cardiovascular and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5-10.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
UniBE Contributor:	Vicedo Cabrera, Ana Maria
Subjects:	600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services
ISSN:	1535-4970
Publisher:	American Thoracic Society
Language:	English
Submitter:	Pubmed Import
Date Deposited:	08 Jun 2022 09:21
Last Modified:	05 Dec 2022 16:20
Publisher DOI:	10.1164/rccm.202111-2657OC
PubMed ID:	35671471
Uncontrolled Keywords:	PM2.5-10 air pollution mortality multi-center study time-series study
URI:	https://boris.unibe.ch/id/eprint/170500