Stojanovski, Klement; Großhans, Helge; Towbin, Benjamin D (2022). Coupling of growth rate and developmental tempo reduces body size heterogeneity in C. elegans. Nature Communications, 13(1), p. 3132. Springer Nature 10.1038/s41467-022-29720-8
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Animals increase by orders of magnitude in volume during development. Therefore, small variations in growth rates among individuals could amplify to a large heterogeneity in size. By live imaging of C. elegans, we show that amplification of size heterogeneity is prevented by an inverse coupling of the volume growth rate to the duration of larval stages and does not involve strict size thresholds for larval moulting. We perturb this coupling by changing the developmental tempo through manipulation of a transcriptional oscillator that controls the duration of larval development. As predicted by a mathematical model, this perturbation alters the body volume. Model analysis shows that an inverse relation between the period length and the growth rate is an intrinsic property of genetic oscillators and can occur independently of additional complex regulation. This property of genetic oscillators suggests a parsimonious mechanism that counteracts the amplification of size differences among individuals during development.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Biology > Institute of Cell Biology 09 Interdisciplinary Units > Microscopy Imaging Center (MIC) |
UniBE Contributor: |
Stojanovski, Klement, Towbin, Benjamin Daniel |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
2041-1723 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
08 Jun 2022 11:05 |
Last Modified: |
05 Dec 2022 16:20 |
Publisher DOI: |
10.1038/s41467-022-29720-8 |
PubMed ID: |
35668054 |
BORIS DOI: |
10.48350/170511 |
URI: |
https://boris.unibe.ch/id/eprint/170511 |
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