Patch test results with the European Baseline Series, 2019/20 - Joint European results of the ESSCAA and the EBSB working groups of the ESCD, and the GEIDACC.

Uter, Wolfgang; Wilkinson, S Mark; Aerts, Olivier; Bauer, Andrea; Borrego, Leopoldo; Brans, Richard; Buhl, Timo; Dickel, Heinrich; Dugonik, Aleksandra; Larese Filon, Francesca; Mercader Garcìa, Pedro; Giménez Arnau, Ana; Patruno, Cataldo; Pesonen, Maria; Pónyai, Györgyi; Rustemeyer, Thomas; Schubert, Steffen; Schuttelaar, Marie-L A; Simon, Dagmar; Stingeni, Luca; ... (2022). Patch test results with the European Baseline Series, 2019/20 - Joint European results of the ESSCAA and the EBSB working groups of the ESCD, and the GEIDACC. Contact dermatitis, 87(4), pp. 343-355. Wiley 10.1111/cod.14170

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BACKGROUND

Continual analyses of patch test results with the European baseline series (EBS) serve both contact allergy surveillance and auditing the value of included allergens.

OBJECTIVES

To present results of current EBS patch testing, obtained in 53 departments in 13 European countries during 2019 and 2020.

METHODS

Anonymised or pseudonymised individual data, and partly aggregated data on demographic/clinical characteristics and patch test rest results with the EBS were prospectively collected and centrally pooled and analysed.

RESULTS

In 2019 and 2020, 22581 patients were patch tested with the EBS. Sensitization to nickel remained most common (19.8 (19.2-20.4)% positivity (95% confidence interval)). Fragrance mix I and Myroxylon pereirae yielded very similar results with 6.80 (6.43-7.19)% and 6.62 (6.25-7.00)% positivity, respectively. Formaldehyde at 2% aq. yielded almost one percentage point more positive reactions than 1% concentration (2.49 (2.16-2.85)% vs. 1.59 (1.33-1.88)); methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and MI alone up to around 5% positives. Among the new additions, propolis was most commonly positive (3.48 (3.16-3.82)%), followed by 2-hydroxyethyl methacrylate (2.32 (2.0-2.68)%).

CONCLUSIONS

Ongoing surveillance on the prevalence of contact sensitization contributes to an up-to-date baseline series containing the most frequent and/or relevant contact sensitizers for routine patch testing in Europe. This article is protected by copyright. All rights reserved.

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