Multicenter Repeatability and Reproducibility of MR Fingerprinting in Phantoms and in Prostatic Tissue.

Lo, Wei-Ching; Bittencourt, Leonardo Kayat; Panda, Ananya; Jiang, Yun; Tokuda, Junichi; Seethamraju, Ravi; Tempany-Afdhal, Clare; Obmann, Verena; Wright, Katherine; Griswold, Mark; Seiberlich, Nicole; Gulani, Vikas (2022). Multicenter Repeatability and Reproducibility of MR Fingerprinting in Phantoms and in Prostatic Tissue. Magnetic resonance in medicine, 88(4), pp. 1818-1827. Wiley-Liss 10.1002/mrm.29264

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PURPOSE

To evaluate multicenter repeatability and reproducibility of T1 and T2 maps generated using MR fingerprinting (MRF) in the International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology MRI system phantom and in prostatic tissues.

METHODS

MRF experiments were performed on 5 different 3 Tesla MRI scanners at 3 different institutions: University Hospitals Cleveland Medical Center (Cleveland, OH), Brigham and Women's Hospital (Boston, MA) in the United States, and Diagnosticos da America (Rio de Janeiro, RJ) in Brazil. Raw MRF data were reconstructed using a Gadgetron-based MRF online reconstruction pipeline to yield quantitative T1 and T2 maps. The repeatability of T1 and T2 values over 6 measurements in the International Society for Magnetic Resonance in Medicine/National Institute of Standards and Technology MRI system phantom was assessed to demonstrate intrascanner variation. The reproducibility between the 4 clinical scanners was assessed to demonstrate interscanner variation. The same-day test-retest normal prostate mean T1 and T2 values from peripheral zone and transitional zone were also compared using the intraclass correlation coefficient and Bland-Altman analysis.

RESULTS

The intrascanner variation of values measured using MRF was less than 2% for T1 and 4.7% for T2 for relaxation values, within the range of 307.7 to 2360 ms for T1 and 19.1 to 248.5 ms for T2 . Interscanner measurements showed that the T1 variation was less than 4.9%, and T2 variation was less than 8.1% between multicenter scanners. Both T1 and T2 values in in vivo prostatic tissue demonstrated high test-retest reliability (intraclass correlation coefficient > 0.92) and strong linear correlation (R2  > 0.840).

CONCLUSION

Prostate MRF measurements of T1 and T2 are repeatable and reproducible between MRI scanners at different centers on different continents for the above measurement ranges.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Obmann, Verena Carola

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0740-3194

Publisher:

Wiley-Liss

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

21 Jun 2022 10:18

Last Modified:

05 Dec 2022 16:21

Publisher DOI:

10.1002/mrm.29264

PubMed ID:

35713379

Uncontrolled Keywords:

MR fingerprinting prostate quantitative mapping repeatability reproducibility

BORIS DOI:

10.48350/170757

URI:

https://boris.unibe.ch/id/eprint/170757

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