Influence of Immunosuppressive Regimen on Diffusivity and Oxygenation of Kidney Transplants-Analysis of Functional MRI Data from the Randomized ZEUS Trial.

Mani, Laila-Yasmin; Cotting, Jasna; Vogt, Bruno; Eisenberger, Ute; Vermathen, Peter (2022). Influence of Immunosuppressive Regimen on Diffusivity and Oxygenation of Kidney Transplants-Analysis of Functional MRI Data from the Randomized ZEUS Trial. Journal of clinical medicine, 11(12), p. 3284. MDPI 10.3390/jcm11123284

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The ZEUS study was a multi-center randomized controlled trial investigating the effect of early conversion from a ciclosporin-based to an everolimus-based regimen on graft function twelve months post-transplantation. In this investigator-initiated sub-study, functional magnetic resonance imaging (fMRI) of kidney grafts was prospectively performed to non-invasively assess differences in graft oxygenation, diffusion and perfusion between groups and time-points using diffusion-weighted imaging (DWI) and blood oxygen level-dependent (BOLD)-MRI. Sixteen patients underwent DWI and BOLD-MRI at months 4.5 and 12 post-transplantation on a 3 Tesla and 1.5 Tesla (n = 3) MR scanner. After exclusion due to image quality, outlier values or missing data, DWI was analyzed for ten subjects; BOLD for eight subjects. The diffusion coefficient ADCD decreased in the CsA-treated group over time, whereas it increased in the EVE group (p = 0.046, medulla). The change in ADCD from months 4.5 to 12 significantly differed between groups in the cortex (p = 0.033) and medulla (p = 0.019). In BOLD, cortico-medullary transverse relaxation rate R2* increased (decreased tissue oxygen) in the CsA-treated and decreased in EVE-treated groups over time. Similarly, R2* values at month 12 were higher in the CsA-treated group compared to the EVE-treated group. There was no significant difference for the perfusion fraction FP. In conclusion, this prospective sub-study of the ZEUS trial suggests an impact of immunosuppressive regimen on fMRI parameters of the kidney graft.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Abt. Magnetresonanz-Spektroskopie und Methodologie, AMSM
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

 Mani, Laila-Yasmin, Vogt, Bruno, Vermathen, Peter

Subjects:

 500 Science > 530 Physics
600 Technology > 610 Medicine & health

ISSN:

 2077-0383

Publisher:

 MDPI

Language:

 English

Submitter:

 Pubmed Import

Date Deposited:

 27 Jun 2022 10:27

Last Modified:

 05 Dec 2022 16:21

Publisher DOI:

 10.3390/jcm11123284

PubMed ID:

 35743353

Uncontrolled Keywords:

 ZEUS study blood oxygen level-dependent (BOLD) calcineurin inhibitors cyclosporin diffusion-weighted imaging (DWI) everolimus functional MRI intravoxel incoherent motion imaging (IVIM) kidney transplantation mTOR inhibitors

BORIS DOI:

 10.48350/170915

URI:

 https://boris.unibe.ch/id/eprint/170915

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