Prediction of recovery from multiple organ dysfunction syndrome in pediatric sepsis patients.

Fan, Bowen; Klatt, Juliane; Moor, Michael M; Daniels, Latasha A; Sanchez-Pinto, Lazaro N; Agyeman, Philipp K A; Schlapbach, Luregn J; Borgwardt, Karsten M (2022). Prediction of recovery from multiple organ dysfunction syndrome in pediatric sepsis patients. Bioinformatics, 38(Supplement1), i101-i108. Oxford University Press 10.1093/bioinformatics/btac229

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MOTIVATION

Sepsis is a leading cause of death and disability in children globally, accounting for ∼3 million childhood deaths per year. In pediatric sepsis patients, the multiple organ dysfunction syndrome (MODS) is considered a significant risk factor for adverse clinical outcomes characterized by high mortality and morbidity in the pediatric intensive care unit. The recent rapidly growing availability of electronic health records (EHRs) has allowed researchers to vastly develop data-driven approaches like machine learning in healthcare and achieved great successes. However, effective machine learning models which could make the accurate early prediction of the recovery in pediatric sepsis patients from MODS to a mild state and thus assist the clinicians in the decision-making process is still lacking.

RESULTS

This study develops a machine learning-based approach to predict the recovery from MODS to zero or single organ dysfunction by 1 week in advance in the Swiss Pediatric Sepsis Study cohort of children with blood-culture confirmed bacteremia. Our model achieves internal validation performance on the SPSS cohort with an area under the receiver operating characteristic (AUROC) of 79.1% and area under the precision-recall curve (AUPRC) of 73.6%, and it was also externally validated on another pediatric sepsis patients cohort collected in the USA, yielding an AUROC of 76.4% and AUPRC of 72.4%. These results indicate that our model has the potential to be included into the EHRs system and contribute to patient assessment and triage in pediatric sepsis patient care.

AVAILABILITY AND IMPLEMENTATION

Code available at https://github.com/BorgwardtLab/MODS-recovery. The data underlying this article is not publicly available for the privacy of individuals that participated in the study.

SUPPLEMENTARY INFORMATION

Supplementary data are available at Bioinformatics online.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Infectiology

UniBE Contributor:

Agyeman, Philipp Kwame Abayie

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1367-4803

Publisher:

Oxford University Press

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

28 Jun 2022 09:50

Last Modified:

20 Jul 2022 15:31

Publisher DOI:

10.1093/bioinformatics/btac229

PubMed ID:

35758775

BORIS DOI:

10.48350/170965

URI:

https://boris.unibe.ch/id/eprint/170965

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