WHO Classification of Tumours 5th Edition: Evolving Issues in Classification, Diagnosis and Prognostication of Prostate Cancer.

Kench, James G; Amin, Mahul B; Berney, Daniel M; Compérat, Eva M; Cree, Ian A; Gill, Anthony J; Hartmann, Arndt; Menon, Santosh; Moch, Holger; Netto, George J; Raspollini, Maria R; Rubin, Mark A; Tan, Puay Hoon; Tsuzuki, Toyonori; Turjalic, Samra; van der Kwast, Theo H; Zhou, Ming; Srigley, John R (2022). WHO Classification of Tumours 5th Edition: Evolving Issues in Classification, Diagnosis and Prognostication of Prostate Cancer. Histopathology, 81(4), pp. 447-458. Wiley 10.1111/his.14711

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The 5th edition of the WHO Classification of Tumours of the Urinary and Male Genital Systems encompasses several updates to the classification and diagnosis of prostatic carcinoma as well as incorporating advancements in assessment of its prognosis, including recent grading modifications. Some of the salient aspects include: 1) recognition that PIN-like carcinoma is not synonymous with a pattern of ductal carcinoma but better classified as a subtype of acinar adenocarcinoma; 2) a specific section on treatment-related neuroendocrine prostatic carcinoma in view of the tight correlation between androgen deprivation therapy and the development of prostatic carcinoma with neuroendocrine morphology, and the emerging data on lineage plasticity; 3) a terminology change of basal cell carcinoma to "adenoid cystic (basal cell) cell carcinoma" given the presence of an underlying MYB::NFIB gene fusion in many cases; 4) discussion of the current issues in the grading of acinar adenocarcinoma and the prognostic significance of cribriform growth patterns; and 5) more detailed coverage of intraductal carcinoma of prostate (IDC-P) reflecting our increased knowledge of this entity, while recommending the descriptive term atypical intraductal proliferation (AIP) for lesions falling short of IDC-P but containing more atypia than typically seen in high-grade prostatic intraepithelial neoplasia (HGPIN). Lesions previously regarded as cribriform patterns of HGPIN are now included in the AIP category. This review discusses these developments, summarising the existing literature, as well as the emerging morphological and molecular data that underpins the classification and prognostication of prostatic carcinoma.

Item Type:	Journal Article (Review Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
UniBE Contributor:	Rubin, Mark Andrew
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1365-2559
Publisher:	Wiley
Language:	English
Submitter:	Pubmed Import
Date Deposited:	28 Jun 2022 09:21
Last Modified:	05 Dec 2022 16:21
Publisher DOI:	10.1111/his.14711
PubMed ID:	35758185
URI:	https://boris.unibe.ch/id/eprint/170968