Richters, Anke; Leliveld, Anna M; Goossens-Laan, Catharina A; Aben, Katja K H; Özdemir, Berna C (2022). Sex differences in treatment patterns for non-advanced muscle-invasive bladder cancer: a descriptive analysis of 3484 patients of the Netherlands Cancer Registry. World journal of urology, 40(9), pp. 2275-2281. Springer 10.1007/s00345-022-04080-6
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PURPOSE
Bladder cancer (BC) is a common malignancy with well-established differences in incidence, clinical manifestation and outcomes between men and women. It is unknown to what extent disparities in outcomes are influenced by differences in treatment approaches. This paper describes treatment patterns among men and women with muscle-invasive BC focusing on curative treatment (radical cystectomy or trimodal therapy).
METHODS
A retrospective population-based cohort study was performed with data from the Netherlands Cancer Registry. All patients newly diagnosed with muscle-invasive, non-advanced BC (MIBC, cT2-4a, N0/X, M0/X) in the years 2018, 2019 and 2020 were identified. Patient and tumor characteristics and initial treatment were compared between men and women with descriptive statistics and multivariable logistic regression analyses.
RESULTS
A total of 3484 patients were diagnosed with non-advanced MIBC in 2018-2020 in the Netherlands, of whom 28% were women. Women had higher T-stage and more often non-urothelial histology. Among all strata of clinical T-stage, women less often received treatment with curative intent (radical cystectomy [RC] or trimodality treatment). Among RC-treated patients, women more often received neoadjuvant treatment (except for cT4a disease). After adjustment for pre-treatment factors, odds ratios were indicative of women having lower probability of receiving curative treatment and RC specifically, and higher probability to receive NAC when treated with RC then men, although not statistically significant.
CONCLUSIONS
Considerable differences in treatment patterns between men and women with MIBC exist. A more considerate role of the patient's sex in treatment decisions could help decrease these differences and might mitigate disparities in outcomes.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Özdemir, Berna |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1433-8726 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
04 Jul 2022 08:30 |
Last Modified: |
05 Dec 2022 16:21 |
Publisher DOI: |
10.1007/s00345-022-04080-6 |
PubMed ID: |
35778577 |
Uncontrolled Keywords: |
Bladder cancer Cancer registry Gender MIBC Sex differences Treatment allocation Treatment pattern Urothelial carcinoma |
BORIS DOI: |
10.48350/171060 |
URI: |
https://boris.unibe.ch/id/eprint/171060 |
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