RANDALL HARRELL, CARL; VOLAREVIC, ANA; PAVLOVIC, DRAGICA; DJONOV, VALENTIN; VOLAREVIC, VLADISLAV (2022). Mesenchymal stem cell-derived exosomes as new remedy for the treatment of inflammatory eye diseases. Biocell, 46(10), pp. 2195-2200. Tech Science Press 10.32604/biocell.2022.020175
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Detrimental immune response has a crucially important role in the development and progression of inflammatory eye diseases. Inflammatory mediators and proteolytic enzymes released by activated immune cells induce serious injury of corneal epithelial cells and retinal ganglion cell which may result in the vision loss. Mesenchymal stem cells (MSCs) are regulatory cells which produce various immunosuppressive factors that modulate phenotype and function of inflammatory immune cells. However, several safety issues, including undesired differentiation and emboli formation, limit clinical use of MSCs. MSC-derived exosomes (MSC-Exos) are nano-sized extracellular vesicles which contain all MSC-derived immunoregulatory factors. Intraocular administration of MSC-Exos efficiently attenuated eye inflammation and significantly improved visual acuity in experimental animals without causing any severe side effects. As cell-free product, MSC-Exos addressed all safety issues related to the transplantation of MSCs. Therefore, MSC-Exos could be considered as potentially new remedy for the treatment of inflammatory eye diseases which efficacy should be explored in up-coming clinical trials.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy |
UniBE Contributor: |
Djonov, Valentin Georgiev, Volarevic, Vladislav |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1667-5746 |
Publisher: |
Tech Science Press |
Language: |
English |
Submitter: |
David Christian Haberthür |
Date Deposited: |
05 Jul 2022 10:55 |
Last Modified: |
05 Dec 2022 16:21 |
Publisher DOI: |
10.32604/biocell.2022.020175 |
BORIS DOI: |
10.48350/171092 |
URI: |
https://boris.unibe.ch/id/eprint/171092 |
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