Maradia, Vivek; van de Water, Steven; Meer, David; Weber, Damien C; Lomax, Antony J; Psoroulas, Serena (2022). Ultra-fast pencil beam scanning proton therapy for locally advanced non-small-cell lung cancers: field delivery within a single breath-hold. Radiotherapy and oncology, 174, pp. 23-29. Elsevier 10.1016/j.radonc.2022.06.018
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PURPOSE
The use of motion mitigation techniques such as breath-hold can reduce the dosimetric uncertainty of lung cancer proton therapy. We studied the feasibility of pencil beam scanning (PBS) proton therapy field delivery within a single breath-hold at PSI's Gantry 2.
METHODS
In PBS proton therapy, the delivery time for a field is determined by the beam-on time and the dead time between proton spots (the time required to change the energy and/or lateral position). We studied ways to reduce beam-on and lateral scanning time, without sacrificing dosimetric plan quality, aiming at a single field delivery time of 15 seconds at maximum. We tested this approach on 10 lung cases with varying target volumes. To reduce the beam-on time, we increased the beam current at the isocenter by developing new beam optics for PSI's PROSCAN beamline and Gantry 2. To reduce the dead time between the spots, we used spot-reduced plan optimization.
RESULTS
We found that it is possible to achieve conventional fractionated (2 Gy(RBE)/fraction) and hypofractionated (6 Gy(RBE)/fraction) field delivery times within a single breath-hold (<15 sec) for a variety non-small-cell lung cancer cases.
CONCLUSION
In summary, the combination of spot reduction and improved beam line transmission is a promising approach for the treatment of mobile tumours within clinically achievable breath-hold durations.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology |
UniBE Contributor: |
Weber, Damien Charles |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0167-8140 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
07 Jul 2022 07:12 |
Last Modified: |
05 Dec 2022 16:21 |
Publisher DOI: |
10.1016/j.radonc.2022.06.018 |
PubMed ID: |
35788354 |
Uncontrolled Keywords: |
Breath-hold Hypofractionation Pencil beam scanning Proton therapy Treatment delivery efficiency |
BORIS DOI: |
10.48350/171114 |
URI: |
https://boris.unibe.ch/id/eprint/171114 |
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