Hippocampal structural alterations in early-stage psychosis: Specificity and relationship to clinical outcomes.

Brunner, Gina; Gajwani, Ruchika; Gross, Joachim; Gumley, Andrew I; Krishnadas, Rajeev; Lawrie, Stephen M; Schwannauer, Matthias; Schultze-Lutter, Frauke; Fracasso, Alessio; Uhlhaas, Peter J (2022). Hippocampal structural alterations in early-stage psychosis: Specificity and relationship to clinical outcomes. NeuroImage: Clinical, 35, p. 103087. Elsevier 10.1016/j.nicl.2022.103087

[img]
Preview
Text
1-s2.0-S2213158222001528-main.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

Hippocampal dysfunctions are a core feature of schizophrenia, but conflicting evidence exists whether volumetric and morphological changes are present in early-stage psychosis and to what extent these deficits are related to clinical trajectories. In this study, we recruited individuals at clinical high risk for psychosis (CHR-P) (n = 108), patients with a first episode of psychosis (FEP) (n = 37), healthy controls (HC) (n = 70) as well as a psychiatric control group with substance abuse and affective disorders (CHR-N: n = 38). MRI-data at baseline were obtained and volumetric as well as vertex analyses of the hippocampus were carried out. Moreover, volumetric changes were examined in the amygdala, caudate, nucleus accumbens, pallidum, putamen and thalamus. In addition, we obtained follow-up functional and symptomatic assessments in CHR-P individuals to examine the question whether anatomical deficits at baseline predicted clinical trajectories. Our results show that the hippocampus is the only structure showing significant volumetric decrease in early-stage psychosis, with FEPs showing significantly smaller hippocampal volumes bilaterally alongside widespread shape changes in the vertex analysis. For the CHR-P group, volumetric decreases were confined to the left hippocampus. However, hippocampal alterations in the CHR-P group were not robustly associated with clinical outcomes, including the persistence of attenuated psychotic symptoms and functional trajectories. Accordingly, our findings highlight that dysfunctions in hippocampal anatomy are an important feature of early-stage psychosis which may, however, not be related to clinical outcomes in CHR-P participants.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy

UniBE Contributor:

Schultze-Lutter, Frauke

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2213-1582

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

07 Jul 2022 10:48

Last Modified:

05 Dec 2022 16:21

Publisher DOI:

10.1016/j.nicl.2022.103087

PubMed ID:

35780662

Uncontrolled Keywords:

Clinical high risk Hippocampus Morphometry Psychosis Subcortex

BORIS DOI:

10.48350/171138

URI:

https://boris.unibe.ch/id/eprint/171138

Actions (login required)

Edit item Edit item
Provide Feedback