Grisotto, Giorgia; Langton, Christine R; Li, Yanping; Bertone-Johnson, Elizabeth R; Baden, Megu Y; Franco, Oscar H; Hu, Frank B; Muka, Taulant; Eliassen, A Heather (2022). Association of plant-based diet and early onset of natural menopause. Menopause, 29(7), pp. 861-867. The North American menopause Society 10.1097/GME.0000000000001985
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OBJECTIVE
To evaluate the association of plant-based diet index (PDI) with early onset of natural menopause in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHSII).
METHODS
We conducted a prospective study with a mean follow-up time of 20 years among premenopausal women living across the US. Participants of the NHS (n = 121,701) and NHSII (n = 116,429) were included from 1984 (age mean [standard deviation]; 44.9 [4.3]) and 1991 (age mean [standard deviation]; 36.4 [4.6]), respectively. Early menopause was self-reported and defined as natural menopause before age 45 years. PDI was derived from semiquantitative food frequency questionnaires administered every 4 years. Cox proportional hazards models were used to assess the association between PDI in quintiles and early menopause in NHS and NHSII separately, and fixed-effect models to pool the results from both cohorts.
RESULTS
During follow-up, 715 and 2,185 women experienced early natural menopause in NHS and NHSII, respectively. After adjustment for potential confounders, no association was observed between PDI and incidence of early natural menopause in either cohort, or when pooling the results from both cohorts, with an exception for unhealthy plant-based diet index which was associated with higher risk of early menopause with increasing levels of consumption (P trend = 0.04).
CONCLUSION
Adherence to PDI was not associated with timing of menopause while unhealthy plant-based diet might be associated with higher risk of experiencing early menopause.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Grisotto, Giorgia, Franco Duran, Oscar Horacio, Muka, Taulant |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1530-0374 |
Publisher: |
The North American menopause Society |
Funders: |
[222] Horizon 2020 ; [226] Swiss School of Public Health Global P3HS Stipend ; [215] National Institute of Health (NIH) |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
08 Jul 2022 09:53 |
Last Modified: |
05 Dec 2022 16:21 |
Publisher DOI: |
10.1097/GME.0000000000001985 |
PubMed ID: |
35796558 |
BORIS DOI: |
10.48350/171187 |
URI: |
https://boris.unibe.ch/id/eprint/171187 |
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