Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV.

Di Liberto, Giovanni; Egervari, Kristof; Kreutzfeldt, Mario; Schürch, Christian M; Hewer, Ekkehard; Wagner, Ingrid; Du Pasquier, Renaud; Merkler, Doron (2022). Neurodegenerative phagocytes mediate synaptic stripping in Neuro-HIV. Brain : a journal of neurology, 145(8), pp. 2730-2741. Oxford University Press 10.1093/brain/awac102

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Glial cell activation is a hallmark of several neurodegenerative and neuroinflammatory diseases. During HIV infection, neuroinflammation is associated with cognitive impairment, even during sustained long-term suppressive antiretroviral therapy. However, the cellular subsets contributing to neuronal damage in the CNS during HIV infection remain unclear. Using post-mortem brain samples from eight HIV patients and eight non-neurological disease controls, we identify a subset of CNS phagocytes highly enriched in LGALS3, CTSB, GPNMB and HLA-DR, a signature identified in the context of ageing and neurodegeneration. In HIV patients, the presence of this phagocyte phenotype was associated with synaptic stripping, suggesting an involvement in the pathogenesis of HIV-associated neurocognitive disorder. Taken together, our findings elucidate some of the molecular signatures adopted by CNS phagocytes in HIV-positive patients and contribute to the understanding of how HIV might pave the way to other forms of cognitive decline in ageing HIV patient populations.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Hewer, Ekkehard Walter

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1460-2156

Publisher:

Oxford University Press

Language:

English

Submitter:

Pubmed Import

Date Deposited:

11 Jul 2022 08:20

Last Modified:

29 Aug 2022 00:14

Publisher DOI:

10.1093/brain/awac102

PubMed ID:

35808999

Uncontrolled Keywords:

HIV neurodegeneration neuroinflammation phagocytes synapses

BORIS DOI:

10.48350/171208

URI:

https://boris.unibe.ch/id/eprint/171208

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