Huwiler, Valentina V; Schönenberger, Katja A; Segesser von Brunegg, Alexander; Reber, Emilie; Mühlebach, Stefan; Stanga, Zeno; Balmer, Maria L (2022). Prolonged Isolated Soluble Dietary Fibre Supplementation in Overweight and Obese Patients: A Systematic Review with Meta-Analysis of Randomised Controlled Trials. Nutrients, 14(13) MDPI 10.3390/nu14132627
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The prevalence of overweight and obesity is rising rapidly, currently affecting 1.9 billion adults worldwide. Prebiotic dietary fibre supplementation is a promising approach to improve weight loss and reduce metabolic complications in overweight and obese subjects due to modifications of the microbiota composition and function. Previous systematic reviews and meta-analyses addressing similar questions revealed discordant evidence and/or are outdated. We searched MEDLINE, Embase, Google Scholar, and forward and backward citations for randomised controlled trials (RCTs) with isolated soluble dietary fibre supplementation for at least 12 weeks in overweight and obese patients measuring body weight, published through April 2022. We expressed the results as mean differences (MDs) using the random-effects model of the metafor package in R and assessed risk of bias using the Cochrane RoB2 tool. We conducted the study according to the PRISMA guidelines and registered the protocol on PROSPERO (CRD42022295246). The participants with dietary fibre supplementation showed a significantly higher reduction in body weight (MD -1.25 kg, 95% CI -2.24, -0.25; 27 RCTs; 1428 participants) accompanied by a significant decrease in BMI, waist circumference, fasting blood insulin, and HOMA-IR compared to the control group. Certainty of evidence was high, paving the way for the implementation of isolated soluble dietary fibre supplementation into clinical practice.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Endokrinologie / Diabetologie (Erwachsene) 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition |
UniBE Contributor: |
Reber, Emilie, Stanga, Zeno, Balmer, Maria Luisa |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2072-6643 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Jul 2022 15:35 |
Last Modified: |
07 Aug 2024 15:45 |
Publisher DOI: |
10.3390/nu14132627 |
PubMed ID: |
35807808 |
Uncontrolled Keywords: |
body weight dietary fibre metabolic disease metabolism microbiome obesity overweight prebiotics supplementation systematic review and meta-analysis |
BORIS DOI: |
10.48350/171211 |
URI: |
https://boris.unibe.ch/id/eprint/171211 |
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