Preventive effect of chitosan gel containing CaneCPI-5 against enamel erosive wear in situ.

Pelá, Vinícius Taioqui; Brito, Leonardo; Taira, Even Akemi; Henrique-Silva, Flávio; Pieretti, Joana Claudio; Seabra, Amedea Barozzi; de Almeida Baldini Cardoso, Cristiane; de Souza, Eduardo Pereira; Groisman, Sonia; Rodrigues, Marcela Charantola; Lussi, Adrian; Saads Carvalho, Thiago; Buzalaf, Marília Afonso Rabelo (2022). Preventive effect of chitosan gel containing CaneCPI-5 against enamel erosive wear in situ. Clinical oral investigations, 26(11), pp. 6511-6519. Springer 10.1007/s00784-022-04600-z

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OBJECTIVE

This study evaluated the preventive effect of a chitosan gel containing CaneCPI-5 against enamel erosion and erosion + abrasion in situ.

METHODS

Sixteen volunteers participated in a crossover, double-blind protocol, comprising 4 phases: (1) no treatment (Nt); (2) chitosan gel (Cg); (3) chitosan gel + 12,300 ppm NaF (Cg + NaF); and (4) chitosan gel + 0.1 mg/mL CaneCPI-5 (Cg + Cane). Volunteers wore an appliance containing 4 specimens. Once/day, they applied the gel (except for Nt) (4 min/specimen). Erosive challenges were performed extra-orally (0.1% citric acid, 90 s, 4 × /day; ERO). Specimens were also abraded (toothbrush, 15 s/specimen, 2 × /day; ERO + ABR). Enamel wear was assessed by profilometry and relative surface reflection intensity (%SRI). Two-way RM-ANOVA/Sidak's tests and Spearman's correlation were used (p < 0.05).

RESULTS

For profilometry, ERO + ABR promoted significantly greater wear when compared with ERO. There was a significant difference among all treatments. The lowest enamel loss occurred for Cg + Cane, followed by Cg + NaF, Cg, and Nt (p < 0.05). The %SRI was significantly lower for ERO + ABR when compared to ERO, only for the Nt group. The greatest %SRI was found for the Cg + NaF and Cg + Cane groups, which did not differ significantly, regardless of the conditions. The lowest %SRI was found for the Nt and Cg groups, which did not differ from each other, regardless of the conditions. The Nt group did not differ significantly from the Cg + NaF (ERO). There was a significant correlation between both analyses.

CONCLUSION

The incorporation of CaneCPI-5 in the chitosan gel prevented erosive wear in situ.

CLINICAL RELEVANCE

These results open a new perspective for the use of CaneCPI-5 in other application vehicles, such as chitosan gel.

Interest & Impact

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