Fromme, Malin; Schneider, Carolin V; Schlapbach, Christoph; Cazzaniga, Simone; Trautwein, Christian; Rader, Dan J; Borradori, Luca; Strnad, Pavel (2022). Comorbidities in lichen planus by phenome-wide association study in two biobank population cohorts. British journal of dermatology, 187(5), pp. 722-729. Wiley-Blackwell 10.1111/bjd.21762
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Br_J_Dermatol_-_2022_-_Fromme_-_Comorbidities_in_lichen_planus_by_phenome_wide_association_study_in_two_biobank_population.pdf - Accepted Version Available under License Publisher holds Copyright. Download (1MB) | Preview |
BACKGROUND
Lichen planus (LP) is a relative frequent mucocutaneous inflammatory disease affecting the skin, skin appendages, and mucosae, including oral mucosae, and less frequently anogenital area, conjunctivae, esophagus, or larynx.
OBJECTIVE
To estimate the association of LP, with emphasis on dermatological and gastrointestinal conditions, in two large independent population cohorts.
METHODS
We performed a phenome-wide association study (PheWAS) and examined conditions associated with LP in two unrelated cohorts, i.e., the multicenter, community-based United Kingdom Biobank (UKB; 501,381 controls; 1130 LP subjects) and the healthcare-associated Penn Medicine Biobank (PMBB; 42702 controls; 764 LP subjects). The data were analyzed in 2021. The "PheWAS" R package was used to perform the PheWAS analyses and Bonferroni correction was utilized to adjust for multiple testing. Odds ratios (ORs) were adjusted for age, sex, and BMI.
RESULTS
In the UKB, PheWAS revealed 133 PheCodes significantly associated with LP and most of them were confirmed in PMBB. Dermatologic and digestive PheCodes were the most abundant: 29 resp. 34 of them were significantly overrepresented in LP individuals from both cohorts. The 29 dermatologic and 12 oral disorders were often highly enriched, whereas hepatic, gastric, esophageal, and intestinal PheCodes displayed ORs in the range of 1.6-4.5. Several autoimmune disorders also exhibited OR>5 in both cohorts.
CONCLUSION
PheWAS in two large unrelated cohorts identified previously unknown comorbidities and may support clinical counseling of LP patients.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Schlapbach, Christoph, Cazzaniga, Simone, Borradori, Luca |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0007-0963 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
18 Jul 2022 14:50 |
Last Modified: |
14 Jul 2023 00:25 |
Publisher DOI: |
10.1111/bjd.21762 |
PubMed ID: |
35819183 |
BORIS DOI: |
10.48350/171315 |
URI: |
https://boris.unibe.ch/id/eprint/171315 |
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