Using Imagination to Integrate Contextual Effects in a Cue-Reactivity Paradigm in Patients with Alcohol Use Disorder: A Functional Magnetic Resonance Imaging Pilot Study.

Fey, Werner Martin; Conring, Frauke; Federspiel, Andrea; Steiner, Leonie; Moggi, Franz; Stein, Maria (2022). Using Imagination to Integrate Contextual Effects in a Cue-Reactivity Paradigm in Patients with Alcohol Use Disorder: A Functional Magnetic Resonance Imaging Pilot Study. Neuropsychobiology, 81(5), pp. 357-369. Karger 10.1159/000525435

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INTRODUCTION

In individuals with alcohol use disorder (AUD), the brain areas underlying cue-induced reactions (e.g., cingulum, striatum, thalamus) and altered activation of these regions have been identified by functional neuroimaging. Neuronal responses to a complex alcohol-related context are yet to investigate. To better understand contextual effects as well as the interplay of cue-induced neural reactions and context exposure, the present study implemented an imagination procedure during functional magnetic resonance imaging (fMRI).

METHODS

Thirteen patients with AUD and 13 healthy controls completed two rounds of a cue-reactivity paradigm inside an MRI scanner. Two individualized imagination tasks were conducted before each of the two cue reactivity tasks. A 2 (group) × 2 (imagination) × 2 (picture-type) analysis of variance (ANOVA) was performed.

RESULTS

The ANOVA revealed a main effect for imagination with higher activation in bilateral thalamus and right caudate nucleus and an interaction effect between imagination and group in right thalamus and left caudate nucleus, due to the patient group reacting stronger during alcohol-related imagination. These structures are involved in relaying sensory information and habit learning. No main or interaction effects of picture type were observed.

CONCLUSIONS

These results support the view that context effects alter the neural responses in thalamus and nucleus caudatus in patients with AUD, and that imagination tasks are suited to incorporate contextual influences in neurophysiological research designs. Future research needs to investigate whether the failure to observe a picture-type effect was due to limited statistical power and omission to individualize picture set, or whether an imagination procedure interferes with the evocation of picture-type effects.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
07 Faculty of Human Sciences > Institute of Psychology > Clinical Psychology and Psychotherapy

UniBE Contributor:

Fey, Werner Martin, Conring, Frauke, Federspiel, Andrea, Moggi, Franz (A), Stein, Maria

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0302-282X

Publisher:

Karger

Language:

English

Submitter:

Pubmed Import

Date Deposited:

20 Jul 2022 10:02

Last Modified:

29 Mar 2023 23:38

Publisher DOI:

10.1159/000525435

PubMed ID:

35850096

Uncontrolled Keywords:

Alcohol use disorder Context Cue reactivity Functional magnetic resonance imaging Imagination task

BORIS DOI:

10.48350/171404

URI:

https://boris.unibe.ch/id/eprint/171404

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