Baggio, Stéphanie; Togni, Giuseppe; Eckerle, Isabella; Vuillemier, Nicolas; Kaiser, Laurent; Gétaz, Laurent (2022). Feasibility of home-based ELISA capillary blood self-testing for anti-SARS-CoV-2 antibodies. Practical Laboratory Medicine, 31, e00290. Elsevier 10.1016/j.plabm.2022.e00290
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Objectives
Serological assays for the presence of anti-SARS-CoV-2 antibodies are crucially needed for research and monitoring of the SARS-CoV-2 pandemic. Antibodies are reliability detected in capillary blood, a minimally invasive and cost-effective alternative to venous blood testing. However, there is a limited knowledge on feasibility of capillary blood self-sampling. This study compared the feasibility of capillary blood self-testing in people aged less than 65 vs. people aged 65 or more. A secondary aim was to investigate the performance of the Hem-Col® (no additive) device compared to venous blood testing.
Design and methods
Data were collected in a prospective study in Switzerland (n = 106). Capillary blood was collected using the Hem-Col® (no additive) device. Feasibility was assessed using 1) collecting the recommended amount of capillary blood and 2) achieving all steps of capillary blood collection. A sample of 5 ml of venous blood was also collected.
Results
For the primary objective, 86.2%/62.1% of patients aged less than 65 collected the recommended amount of capillary blood/achieved all steps vs. 62.5%/39.6% of patients aged 65 or more (p = .006/p = .022). For the secondary objective, the correlation between capillary and venous blood was r = 0.992 and kappa = 1.
Conclusions
Capillary blood self-testing appeared as a feasible and reliable alternative to venous blood testing. Such alternative would improve access to serological testing and spare health care resources. However, the difference between age groups should be considered when using self-sampling devices. Help should be developed for older people, such as phone counseling or encouraging asking younger family members for help.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM) |
UniBE Contributor: |
Baggio, Stéphanie |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
2352-5517 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
20 Jul 2022 09:34 |
Last Modified: |
05 Dec 2022 16:21 |
Publisher DOI: |
10.1016/j.plabm.2022.e00290 |
PubMed ID: |
35846110 |
Uncontrolled Keywords: |
Antibodies COVID-19 Covid-19, Coronavirus disease of 2019 ELISA, Enzyme-linked immunosorbent assays IgG, Immunoglobulin G OR, Odd-ratio RT-PCR, Real-time reverse transcription–polymerase chain reaction SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 Serological testing |
BORIS DOI: |
10.48350/171413 |
URI: |
https://boris.unibe.ch/id/eprint/171413 |
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