Schneider, Caroline; González-Jaramillo, Nathalia; Marcin, Thimo; Campbell, Kristin L; Suter, Thomas; Bano, Arjola; Wilhelm, Matthias; Eser, Prisca (2022). Time-Dependent Effect of Anthracycline-Based Chemotherapy on Central Arterial Stiffness: A Systematic Review and Meta-Analysis. Frontiers in cardiovascular medicine, 9, p. 873898. Frontiers 10.3389/fcvm.2022.873898
|
Text
fcvm-09-873898.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (2MB) | Preview |
Background and Aims
Anthracycline-based chemotherapy (ANTH-BC) has been proposed to increase arterial stiffness, however, the time-dependency of these effects remain unclear. This systematic review and meta-analysis aimed to investigate the time-dependent effect of ANTH-BC on markers of central aortic stiffness, namely aortic distensibility (AD) and pulse-wave-velocity (PWV) in cancer patients.
Methods
An extensive literature search without language restrictions was performed to identify all studies presenting longitudinal data on the effect of ANTH-BC on either AD and/or central PWV in cancer patients of all ages. An inverse-variance weighted random-effect model was performed with differences from before to after chemotherapy, as well as for short vs. mid-term effects.
Results
Of 2,130 articles identified, 9 observational studies with a total of 535 patients (mean age 52 ± 11; 73% women) were included, of which four studies measured AD and seven PWV. Short-term (2-4 months), there was a clinically meaningful increase in arterial stiffness, namely an increase in PWV of 2.05 m/s (95% CI 0.68-3.43) and a decrease in AD (albeit non-significant) of -1.49 mmHg-1 (-3.25 to 0.27) but a smaller effect was observed mid-term (6-12 months) for PWV of 0.88 m/s (-0.25 to 2.02) and AD of -0.37 mmHg-1 (-1.13 to 0.39). There was considerable heterogeneity among the studies.
Conclusions
Results from this analysis suggest that in the short-term, ANTH-BC increases arterial stiffness, but that these changes may partly be reversible after therapy termination. Future studies need to elucidate the long-term consequences of ANTH-BC on arterial stiffness, by performing repeated follow-up measurements after ANTH-BC termination.
Systematic Review Registration
[www.crd.york.ac.uk/prospero/], identifier [CRD42019141837].
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
Graduate School: |
Graduate School for Health Sciences (GHS) |
UniBE Contributor: |
Schneider, Caroline, Gonzalez Jaramillo, Nathalia, Marcin, Thimo, Suter, Thomas, Bano, Arjola, Wilhelm, Matthias, Eser, Prisca Christina |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
2297-055X |
Publisher: |
Frontiers |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
25 Jul 2022 07:43 |
Last Modified: |
02 Mar 2023 23:36 |
Publisher DOI: |
10.3389/fcvm.2022.873898 |
PubMed ID: |
35865379 |
Uncontrolled Keywords: |
aortic distensibility breast cancer lymphoma pulse-wave-velocity vasculotoxicity |
BORIS DOI: |
10.48350/171501 |
URI: |
https://boris.unibe.ch/id/eprint/171501 |
Actions (login required)
 |
Edit item |