Garbazza, Corrado; Cirignotta, Fabio; D'Agostino, Armando; Cicolin, Alessandro; Hackethal, Sandra; Wirz-Justice, Anna; Cajochen, Christian; Manconi, Mauro (2022). Sustained remission from perinatal depression after bright light therapy: a pilot randomised, placebo-controlled trial. Acta psychiatrica Scandinavica, 146(4), pp. 350-356. Wiley-Blackwell 10.1111/acps.13482
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Acta_Psychiatr_Scand_-_2022_-_Garbazza_-_Sustained_remission_from_perinatal_depression_after_bright_light_therapy_a_pilot.pdf - Accepted Version Available under License Publisher holds Copyright. Download (606kB) | Preview |
OBJECTIVE
Perinatal depression (PND) is a severe complication of pregnancy, affecting both mothers and newborns. Bright light therapy (BLT) has only been tested in a few studies for treating either antenatal or postnatal depression. We conducted a pilot trial to investigate the efficacy and safety of BLT for PND occurring at any time across the perinatal period.
METHODS
A single-blind RCT was carried out in women with an EPDS >12 from the 2nd gestational trimester until 9 months postpartum. Participants received either 30-minutes morning BLT (10'000 lux) or dim red light (DRL, 19 lux) for 6 weeks.
RESULTS
Twenty-two women were randomised to BLT (n = 11) or DRL (n = 11). Among those receiving BLT, 73% achieved remission (improvement ≥50%, EPDS score ≤ 12), in contrast to 27% in the DRL group (p = 0.04). A significant influence of time on EPDS score and group-time interaction emerged, with a greater reduction in the BLT-group across the follow-up period. No women in either group reported major side effects.
CONCLUSION
Morning BLT induced a significant remission from PND as compared to DRL and this effect was maintained across the perinatal period. BLT showed an excellent safety profile and was well-tolerated, thus representing a valid therapeutic strategy in this vulnerable perinatal population.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Manconi, Mauro |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0001-690X |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
27 Jul 2022 10:08 |
Last Modified: |
26 Jul 2023 00:25 |
Publisher DOI: |
10.1111/acps.13482 |
PubMed ID: |
35876837 |
Uncontrolled Keywords: |
light therapy postpartum depression pregnancy |
BORIS DOI: |
10.48350/171529 |
URI: |
https://boris.unibe.ch/id/eprint/171529 |
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