Determinants of antibody response to severe acute respiratory syndrome coronavirus 2 mRNA vaccines in people with HIV.

Chammartin, Frédérique; Kusejko, Katharina; Pasin, Chloé; Trkola, Alexandra; Briel, Matthias; Amico, Patrizia; Stoekle, Marcel P; Eichenberger, Anna L; Hasse, Barbara; Braun, Dominique L; Schuurmans, Macé M; Müller, Thomas F; Tamm, Michael; Mueller, Nicolas J; Rauch, Andri; Koller, Michael T; Günthard, Huldrych F; Bucher, Heiner C; Speich, Benjamin and Abela, Irene A (2022). Determinants of antibody response to severe acute respiratory syndrome coronavirus 2 mRNA vaccines in people with HIV. AIDS, 36(10), pp. 1465-1468. Lippincott Williams & Wilkins 10.1097/QAD.0000000000003246

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We identified determinants of SARS-CoV-2 mRNA vaccine antibody response in people with HIV (PWH). Antibody response was higher among PWH less than 60 years, with CD4+ cell count superior to 350 cells/μl and vaccinated with mRNA-1273 by Moderna compared with BNT162b2 by Pfizer-BioNTech. Preinfection with SARS-CoV-2 boosted the antibody response and smokers had an overall lower antibody response. Elderly PWH and those with low CD4+ cell count should be prioritized for booster vaccinations.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Eichenberger, Anna

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0269-9370

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Pubmed Import

Date Deposited:

27 Jul 2022 08:48

Last Modified:

05 Dec 2022 16:22

Publisher DOI:

10.1097/QAD.0000000000003246

PubMed ID:

35876706

BORIS DOI:

10.48350/171530

URI:

https://boris.unibe.ch/id/eprint/171530

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