Conserved requirement of autophagy-related effectors during coronavirus replication.

Brüggemann, Yannick; Kratzel, Annika; Almeida, Lea; Kelly, Jenna N; Thiel, Volker; Pfaender, Stephanie (2023). Conserved requirement of autophagy-related effectors during coronavirus replication. Autophagy, 19(2), pp. 731-733. Landes Bioscience 10.1080/15548627.2022.2100617

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The recurrence of zoonotic transmission events highlights the need for novel treatment strategies against emerging coronaviruses (CoVs), namely SARS-CoV, MERS-CoV and most notably SARS-CoV-2. Our recently performed genome-wide CRISPR knockout screen revealed a list of conserved pan-coronavirus as well as MERS-CoV or HCoV-229E-specific host dependency factors (HDF) essential during the viral life cycle. Intriguingly, we identified the macroautophagy/autophagy pathway-regulating immunophilins FKBP8, TMEM41B, and MINAR1 as conserved MERS-CoV, HCoV-229E, SARS-CoV, and SARS-CoV-2 host factors, which further constitute potential targets for therapeutic intervention by clinically approved drugs.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Kratzel, Annika, Almeida, Lea, Kelly, Jenna Nicole, Thiel, Volker Earl

Subjects:

600 Technology > 630 Agriculture

ISSN:

1554-8627

Publisher:

Landes Bioscience

Language:

English

Submitter:

Pubmed Import

Date Deposited:

28 Jul 2022 09:16

Last Modified:

18 Jan 2023 00:12

Publisher DOI:

10.1080/15548627.2022.2100617

PubMed ID:

35875965

Uncontrolled Keywords:

Antiviral target CRISPR screen autophagy coronavirus host factor

URI:

https://boris.unibe.ch/id/eprint/171532

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