Insights Into the Pathogenesis of Bullous Pemphigoid: The Role of Complement-Independent Mechanisms.

Cole, Connor; Vinay, Keshavamurthy; Borradori, Luca; Amber, Kyle T (2022). Insights Into the Pathogenesis of Bullous Pemphigoid: The Role of Complement-Independent Mechanisms. Frontiers in immunology, 13, p. 912876. Frontiers Research Foundation 10.3389/fimmu.2022.912876

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Bullous pemphigoid is an autoimmune blistering disease caused by autoantibodies targeting BP180 and BP230. While deposits of IgG and/or complement along the epidermal basement membrane are typically seen suggesting complement -mediated pathogenesis, several recent lines of evidence point towards complement-independent pathways contributing to tissue damage and subepidermal blister formation. Notable pathways include macropinocytosis of IgG-BP180 complexes resulting in depletion of cellular BP180, direct induction of pro-inflammatory cytokines from keratinocytes, as well as IgE autoantibody- and eosinophil-mediated effects. We review these mechanisms which open new perspectives on novel targeted treatment modalities.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Borradori, Luca

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-3224

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Pubmed Import

Date Deposited:

26 Jul 2022 13:05

Last Modified:

05 Dec 2022 16:22

Publisher DOI:

10.3389/fimmu.2022.912876

PubMed ID:

35874745

Uncontrolled Keywords:

BP180 BP230 autoimmune blistering diseases bullous pemphigoid complement - immunological terms eosinophils – immunology igE (Immunoglobulin E)

BORIS DOI:

10.48350/171535

URI:

https://boris.unibe.ch/id/eprint/171535

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