Role of prostate and bone stromal cells on prostate cancer progression.

Karkampouna, Sofia; Kruithof-de Julio, Marianna; Thalmann, George N (2022). Role of prostate and bone stromal cells on prostate cancer progression. American journal of clinical and experimental urology, 10(3), pp. 180-187. e-Century Publishing

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Prostate cancer is a highly heterogeneous disease, often manifesting in a metastatic form to the bone. Complex tumour cells and surrounding microenvironment interactions are important determinants of disease progression and therapy resistance. Here, we provide an overview of some of the early studies that recognized the pro-tumourigenic role of prostate stroma, particularly fibroblasts, bone stromal components, and its permissive tumour properties. This article is written in memory of Prof. Dr LWK Chung and his contributions. Prostate and bone metastasis stroma concepts emerging from his work are now more actively being pursued by the authors of this article and others in the field.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Karkampouna, Sofia; Kruithof-de Julio, Marianna and Thalmann, George

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2330-1910

Publisher:

e-Century Publishing

Language:

English

Submitter:

Pubmed Import

Date Deposited:

26 Jul 2022 13:02

Last Modified:

26 Jul 2022 13:02

PubMed ID:

35874291

Uncontrolled Keywords:

LNCaP Prostate cancer bone metastasis organoids stroma tumour microenvironment

URI:

https://boris.unibe.ch/id/eprint/171538

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