Antibiotics for Preventing Recurrent Urinary Tract Infection: Systematic Review and Meta-analysis.

Jent, Philipp; Berger, Julia; Kuhn, Annette; Trautner, Barbara W; Atkinson, Andrew; Marschall, Jonas (2022). Antibiotics for Preventing Recurrent Urinary Tract Infection: Systematic Review and Meta-analysis. Open Forum Infectious Diseases, 9(7), ofac327. Oxford University Press 10.1093/ofid/ofac327

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Recurrent urinary tract infections are a common health problem. The only comprehensive synthesis on antibiotic prophylaxis in the last 15 years has been a guideline-embedded meta-analysis. We conducted a systematic review and meta-analysis of randomized controlled trials published up to October 13, 2020, evaluating patients age ≥12 years with either ≥2 episodes of lower urinary tract infection (UTI) within 6 months or ≥3 in the past year. Placebo or antibiotics were allowed as comparators. Study quality was low. In the 11 placebo-controlled trials, the risk for developing UTI was 85% lower with prophylaxis in comparison with placebo (risk ratio [RR], 0.15; 95% CI, 0.08-0.29). In the 9 head-to-head trials, the efficacy of the antibiotic agents appeared similar: The pooled RR indicated no difference between nitrofurantoin and comparators (RR, 1.01; 95% CI, 0.74-1.37), nor trimethoprim (+/- sulfamethoxazole; RR, 1.34; 95% CI, 0.89-2.03) or norfloxacin and comparators (RR, 1.17; 95% CI, 0.43-1.70). Studies comparing intermittent (postcoital) with continuous strategies revealed intermittent application to be equally effective.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Jent, Philipp, Kuhn, Annette, Atkinson, Andrew David

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2328-8957

Publisher:

Oxford University Press

Language:

English

Submitter:

Pubmed Import

Date Deposited:

29 Jul 2022 16:18

Last Modified:

24 Apr 2023 10:37

Publisher DOI:

10.1093/ofid/ofac327

PubMed ID:

35899289

Uncontrolled Keywords:

UTI antibiotic prophylaxis cystitis meta-analysis recurrent urinary tract infection

BORIS DOI:

10.48350/171635

URI:

https://boris.unibe.ch/id/eprint/171635

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