Malézieux-Picard, Astrid; Abdul, Fabien; Herrmann, François R.; Caillon, Aurélie; Ribaux, Pascale; Cambet, Yves; Yerly, Sabine; Baggio, Stéphanie; Vernaz, Nathalie; Zekry, Dina; Krause, Karl-Heinz; Preynat-Seauve, Olivier; Prendki, Virginie (2022). Decreased Levels of SARS-CoV-2 Fusion-Inhibitory Antibodies in the Serum of Aged COVID-19 Patients. Diagnostics, 12(8), p. 1813. MDPI 10.3390/diagnostics12081813
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Background: The SARS-CoV-2 pandemic was particularly devastating for elderly people, and the underlying mechanisms of the disease are still poorly understood. In this study, we investigated fusion inhibitory antibodies (fiAbs) in elderly and younger COVID-19 patients and analyzed predictive factors for their occurrence. Methods: Data and samples were collected in two cohorts of hospitalized patients. A fusion assay of SARS-CoV-2 spike-expressing cells with ACE2expressing cells was used to quantify fiAbs in the serum of patients. Results: A total of 108 patients (52 elderly (mean age 85 ± 7 years); 56 young (mean age 52 ± 10 years)) were studied. The concentrations of fiAbs were lower in geriatric patients, as evidenced at high serum dilutions (1/512). The association between fiAbs and anti-Spike Ig levels was weak (correlation coefficient < 0.3), but statistically significant. Variables associated with fusion were the delay between the onset of symptoms and testing (HR = −2.69; p < 0.001), clinical frailty scale (HR = 4.71; p = 0.035), and WHO severity score (HR = −6.01, p = 0.048). Conclusions: Elderly patients had lower fiAbs levels after COVID-19 infection. The decreased fiAbs levels were associated with frailty.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM) |
UniBE Contributor: |
Baggio, Stéphanie |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
2075-4418 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Doris Kopp Heim |
Date Deposited: |
04 Aug 2022 12:17 |
Last Modified: |
05 Dec 2022 16:22 |
Publisher DOI: |
10.3390/diagnostics12081813 |
PubMed ID: |
36010162 |
Uncontrolled Keywords: |
SARS-CoV-2 fusion inhibitory antibody; elderly; frailty |
BORIS DOI: |
10.48350/171744 |
URI: |
https://boris.unibe.ch/id/eprint/171744 |
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